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Article Abstract
Fractionation of a methanol extract of leaves led to the identification of five new quinoline alkaloids (, , , , and ), three new coumarins (, , and ), and 20 known compounds. The structures were determined by analysis of 1D and 2D NMR spectroscopic data. The absolute configuration of was proposed by electronic circular dichroism calculation. Among the compounds tested in the phenotypic screening to measure adiponectin secretion in human bone marrow mesenchymal stem cells, metabolites and stimulated adiponectin secretions with EC values of 13.8 and 25.8 μM, respectively. Further PPARγ binding assay and molecular modeling suggested that compounds and are selective PPARγ agonists.
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| http://dx.doi.org/10.1021/acs.jnatprod.2c00844 | DOI Listing |
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