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Background And Objectives: Annual preparticipation physical evaluation (PPE) is used in the United States to screen adolescents for potential causes of sudden cardiac death. The American Heart Association recommends 14 screening elements of history and physical examination. This study sought to define the utilization of these screening elements by each of the 50 states before high school athletics.
Methods: PPE forms were obtained from the public website of the high school athletics governing body in every state. Form content was analyzed to identify which of the 14 screening elements were explicitly fulfilled. Additional PPE forms provided by private/parochial schools, other professional societies, or independent groups were excluded from this study.
Results: A total of 48 states (96%) had PPE forms posted online. The remaining 2 states (4%) deferred the specific method of PPE documentation to individual school districts and provided no standardized form. Of the 48 states providing PPE forms, 13 (27%) included all 14 American Heart Association screening elements. The median criteria included by each state was 11 (range 3-14). The 3 criteria most commonly absent were (1) the examination of femoral pulses to exclude coarctation (58%), (2) a family history of specific inherited cardiac disease (31%), and (3) personal history of hypertension (27%).
Conclusions: Annual preparticipation forms are important screening tools. Only a minority of states include all 14 cardiac screening elements recommended by the American Heart Association.
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http://dx.doi.org/10.1542/peds.2022-056798 | DOI Listing |
J Urban Health
September 2025
School of Architecture and Design, Harbin Institute of Technology, Harbin, 150001, China.
Street-level environments play a vital role in children's development by promoting their physical activity, cognitive growth, and overall development. This study systematically reviews the measurement tools available to assess street environments according to children's needs. This systematic review was conducted according to the PRISMA-COSMIN guidelines.
View Article and Find Full Text PDFFunct Integr Genomics
September 2025
The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming, China.
Ischemic stroke (IS) has high morbidity/mortality with limited treatments. This study screened core copper homeostasis-related genes in IS and validated their function as precise intervention targets. Human IS gene chip data were retrieved from GEO, and copper homeostasis genes from multiple databases.
View Article and Find Full Text PDFJ Virol
September 2025
Genome Regulation and Cell Signaling, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, Pennsylvania, USA.
Unlabelled: Adenoviruses are double-stranded DNA viruses widely used as platforms for vaccines, oncolytics, and gene delivery. However, tools for studying adenoviral gene expression in real time during infection remain limited. Here, we describe a set of fluorescent and bioluminescent reporter viruses built using the modular AdenoBuilder reverse genetics system and informed by high-resolution maps of Ad5 transcription.
View Article and Find Full Text PDFACS Nano
September 2025
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Optical imaging offers high sensitivity and specificity for noninvasive cancer detection, but conventional techniques suffer from limited probe accumulation, tissue autofluorescence, and poor depth resolution. Afterglow luminescence overcomes autofluorescence by emitting persistent light after excitation, yet its utility in vivo remains hindered by weak tumor enrichment and two-dimensional readouts lacking spatial context. Here, we report luminescent-magnetic nanoparticles (LM-NPs) coencapsulating luminescent trianthracene (TA) molecules and iron oxide cores within the amphiphilic polymer pluronic-F127.
View Article and Find Full Text PDFEur J Case Rep Intern Med
August 2025
Department of Internal Medicine, Wayne State University School of Medicine, Trinity Health Oakland Hospital, Pontiac, USA.
Background: Invasive central nervous system (CNS) aspergillosis is rare among human immunodeficiency virus (HIV)-positive patients due to preserved neutrophil function, despite significant CD4+ T-cell depletion. Diagnosis typically requires histopathologic confirmation, but polymerase chain reaction (PCR) testing has introduced new challenges due to its high sensitivity but limited specificity.
Case Presentation: We describe a newly diagnosed 43-year-old HIV-positive male with concurrent Hodgkin lymphoma who presented with progressive neurological decline and a ring-enhancing brain lesion.