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http://dx.doi.org/10.3389/fpls.2022.1069886 | DOI Listing |
Front Rehabil Sci
August 2025
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, United States.
Introduction: Spinal cord injury (SCI) presents a significant burden to patients, families, and the healthcare system. The ability to accurately predict functional outcomes for SCI patients is essential for optimizing rehabilitation strategies, guiding patient and family decision making, and improving patient care.
Methods: We conducted a retrospective analysis of 589 SCI patients admitted to a single acute rehabilitation facility and used the dataset to train advanced machine learning algorithms to predict patients' rehabilitation outcomes.
Med Acupunct
August 2025
Clinical Translational Science Institute, Indiana University School of Medicine, Bloomington, Indiana, USA.
Med Acupunct
August 2025
Division of Pediatric Hematology/Oncology/Stem Cell Transplant, Seattle Institute of East Asian Medicine, Seattle, Washington, USA.
Front Immunol
September 2025
Department of Pathological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, United States.
Oncolytic virotherapy (OVT) has emerged as a promising and innovative cancer treatment strategy that harnesses engineered viruses to selectively infect, replicate within, and destroys malignant cells while sparing healthy tissues. Beyond direct oncolysis, oncolytic viruses (OVs) exploit tumor-specific metabolic, antiviral, and immunological vulnerabilities to reshape the tumor microenvironment (TME) and initiate systemic antitumor immunity. Despite promising results from preclinical and clinical studies, several barriers, including inefficient intratumoral virus delivery, immune clearance, and tumor heterogeneity, continue to limit the therapeutic advantages of OVT as a standalone modality and hindered its clinical success.
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August 2025
Institute of Immunity & Transplantation, University College London Division of Infection & Immunity, London, United Kingdom.