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http://dx.doi.org/10.1038/s41419-022-05427-y | DOI Listing |
Foods
August 2025
Non-Clinical Evaluation Center, Biomedical Research Institute, Jeonbuk National University Hospital, Jeonjusi 54907, Republic of Korea.
In the original publication [...
View Article and Find Full Text PDFEur J Pharmacol
August 2025
Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address:
Sirtuin 1 (SIRT1) has emerged as a promising therapeutic target for many diseases such as neurodegenerative disorders. Resveratrol, a plant polyphenol, is known to induce SIRT1 expression and activity. To excavate active compounds that can increase SIRT1 transcription from FDA-approved drugs, a cell-based SIRT1 up-regulator screening assay was developed.
View Article and Find Full Text PDFFront Pharmacol
July 2025
Department of Neurosurgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
[This corrects the article DOI: 10.3389/fphar.2020.
View Article and Find Full Text PDFFree Radic Biol Med
March 2025
NeuroDiscovery Lab, Mitsubishi Tanabe Pharma America, Cambridge, MA, 02139, USA. Electronic address:
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss along with pathological mislocalization of TAR DNA-binding protein 43 (TDP-43), a protein implicated in RNA metabolism. Although edaravone, a free-radical scavenger, has been approved for ALS treatment, its precise mechanism of action is not fully understood, particularly in relation to TDP-43 pathology. Here, we investigated the effects of edaravone on induced pluripotent stem cell (iPSC)-derived motor neurons in a patient with ALS harboring a TDP-43 mutation.
View Article and Find Full Text PDFSci Rep
February 2025
College of Veterinary Medicine, Hebei Agricultural University, No. 2596 Lekai South Street, Lianchi District, Baoding, 071000, People's Republic of China.
Ischaemia-reperfusion (IR) damage is an inevitable adverse effect of liver surgery. Recent research has found that IR damage is involved in severe mitochondrial dysfunction. Mitochondrial biosynthesis and dynamics control mitochondrial mass, distribution, and function.
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