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Correction for 'Pd-Catalysed [3 + 2]-cycloaddition towards the generation of bioactive bis-heterocycles/identification of COX-2 inhibitors analysis' by Elagandhula Sathish , , 2022, , 4746-4752, https://doi.org/10.1039/D2OB00467D.
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http://dx.doi.org/10.1039/d2ob90148j | DOI Listing |
Beilstein J Org Chem
September 2025
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997, Moscow, Russia.
Thioformylium methylide, which is readily generated from chloromethyl(trimethylsilyl)methyl sulfide by the action of fluoride, is used for the synthesis of spirocyclic derivatives from arylidene-azolones. Four types of the corresponding heterocycles have been studied. A series of 7-thia-3-azaspiro[4.
View Article and Find Full Text PDFOrg Lett
September 2025
College of Chemistry, International Phosphorus Laboratory, Zhengzhou University, Zhengzhou 450001, P. R. China.
The classical 1,3-dipolar cycloaddition reaction predominantly generates five-membered heterocycles through cycloaddition between 1,3-dipoles and unsaturated hydrocarbons, such as alkenes or alkynes. Herein, we report a light-mediated approach that employs saturated amines as alternatives to conventional unsaturated hydrocarbons, enabling their reaction with -imino(iso)quinolinium ylides to achieve efficient synthesis of pyrazolo-fused (iso)quinoline core structures. This method demonstrates operational simplicity, mild reaction conditions, and excellent functional group compatibility.
View Article and Find Full Text PDFChem Sci
August 2025
College of Chemistry and Materials Science, Key Laboratory of Chemical Biology of Hebei Province, Hebei Research Center of the Basic Discipline of Synthetic Chemistry, Institute of Life Science and Green Development Hebei University Baoding Hebei 071002 P. R. China
The photocatalytic oxidative dipolar [3 + 2] cycloaddition reaction is a promising green approach for producing pyrrolo[2,1-]isoquinolines. However, developing sustainable cycloaddition methods with heterogeneous photocatalysts is still in its infancy, largely owing to their low reactivity and photostability. Herein, we propose a charge-oxygen synergy strategy through a dual-engineered covalent organic framework (COF) by integrating π-spacers with donor-acceptor motifs to promote intermolecular cycloaddition.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Department of Chemistry and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen, 518055, China.
The application of chalcogen bonding catalysis has been largely confined to benchmark reactions due to the limited structural diversity and activating ability of the catalysts, especially those derived from tellurium. Herein, we present a group of rationally designed bis-telluronium catalysts and realize the first application of chalcogen bonding donor in catalyzing the [4 + 2] cycloaddition reaction between azetidines and non-activated alkenes or alkynes. This chemistry demonstrates excellent functional group tolerance and offers an efficient avenue to access the piperidine and tetrahydropyridine architectures in generally moderate-to-good efficiency.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Freie Universität Berlin, Institute of Chemistry and Biochemistry, Fabeckstr. 34/36, 14195, Berlin.
The photolysis of 1-phosphabarrelenes, generated from 3,5-diarylphosphinines and benzyne in a [4 + 2] cycloaddition reaction, affords hitherto unknown 2-phosphasemibullvalenes di-π-methane rearrangement reaction. These compounds occur only as intermediates, while subsequent and rapid dimerization to 6-membered, cyclic diphosphanes with a P-P bond was observed. The results are in stark contrast to the photochemical conversion of 1-phosphabarrelenes, obtained from 2,4,6-triarylphosphinines and a strong dienophile.
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