Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Left ventricular (LV) remodelling (REM) ensuing after ST-elevation myocardial infarction (STEMI), has typically been studied by echocardiography, which has limitations, or cardiac magnetic resonance (CMR) in early phase that may overestimate infarct size (IS) due to tissue edema and stunning. This prospective, multicenter study investigated LV-REM performing CMR in the subacute phase, and 6 months after STEMI.
Methods And Results: patients with first STEMI undergoing successful primary angioplasty were consecutively enrolled. CMR was done at 30-days and 6-months. Primary endpoint was prevalence at 6 months of LV-REM [≥12% increase in LV end-diastolic volume index (LV-REM)]; LV-REM by end-systolic volume index increase ≥12% (LV-REM) was also calculated. Of 325 patients enrolled, 193 with a full set of research-quality CMR images were analyzed. LV-REM and LV-REM were present in 36/193 (19%) and 34/193 (18%) patients, respectively. At follow up, LV ejection fraction (EF) improved in patients with or without LV-REM, whilst it decreased in those with LV-REM (p < 0.001 for interaction). Considering predictors of LV-REM, IS in the highest tertile was clearly separated from the two lower tertiles. In LV-REM, the highest tertile was associated with significantly higher LV-EDV, LV-ESV, and lower EF.
Conclusions: In a contemporary cohort of STEMI patients studied by CMR, prevalence of LV-REM was lower than previously reported. Importantly, our data indicate that LV-REM might not be "adverse" per se, but rather "compensatory", being associated with LV-EF improvement at follow-up. Conversely, LV-REM might be an "adverse" phenomenon associated with decreased LV-EF, driven by IS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2022.11.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brain Metabolite Concentrations in Neonates with Congenital Heart Disease Before and After Cardiac Surgery.
Neuroimage
September 2025
Developing Brain Institute, Children's National Hospital, Washington, D.C. USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C. USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, W
The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T-weighted brain images and MRS data were acquired in the cerebellum, right frontal lobe and basal ganglia.
View Article and Find Full Text PDFVisually assessed ischaemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.
J Cardiovasc Magn Reson
September 2025
Royal Brompton and Harefield Hospitals, part of Guy's and St Thomas' NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, UK. Electronic address:
Background: Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium.
Objectives: To assess how changes in cardiac reperfusion and remodelling associate with symptom improvement in patients undergoing CABG METHODS: Patients awaiting elective CABG completed serial quality of life questionnaires and detailed CMR at baseline and at 6-12 months post CABG as per protocol. Automated fully quantitative stress and rest myocardial blood flow was calculated, alongside assessment of the visual ischaemic burden.
Biomarker-Based Surveillance in Heart Transplant Rejection.
Can J Cardiol
September 2025
Division of Cardiology, Hartford HealthCare Heart and Vascular Institute, Hartford, CT, USA. Electronic address:
Post-transplant rejection surveillance remains a cornerstone of heart transplant care. Although endomyocardial biopsy (EMB) has long been the gold standard for detecting rejection, its invasive nature, interobserver variability in histologic interpretation, and limitations in distinguishing between acute cellular rejection (ACR) and antibody-mediated rejection have prompted interest in noninvasive techniques. Traditional biomarkers- such as troponin, C-reactive protein, brain natriuretic peptide, and donor-specific antibodies- offer supplementary assessments of graft function but lack the specificity and sensitivity required to be standalone markers.
View Article and Find Full Text PDFSampling of non-Gaussian Ensemble Average Propagators for the simulation of diffusion magnetic resonance images.
Magn Reson Med
September 2025
Laboratorio de Procesado de Imagen (LPI), Universidad de Valladolid, Valladolid, Spain.
Purpose: (a) To design a methodology for drawing random samples of any Ensemble Average Propagator (EAP) (b) to modify the KomaMRI simulator to accommodate them as realistic spin movements to simulate diffusion MRI (dMRI) and (c) to compare these simulations with those based on the Diffusion Tensor (DT) model.
Theory And Methods: The rejection method is used for random sampling of EAPs: starting from a probability law that is easily sampled, and whose density function wraps the target EAP, samples are accepted when they lie inside the targeted region. This is used to sample the EAP as described by Mean Apparent Propagator MRI (MAP-MRI) and in Spherical Convolution (SC) based on Spherical Harmonics (SH).
Molecular Layer Atrophy Mediates the Association of Cumulative Blood Pressure Exposure With Cognitive Decline.
J Am Heart Assoc
September 2025
Department of Radiology, Beijing Friendship Hospital Capital Medical University Beijing China.
Background: High blood pressure (BP) is a known risk factor for cognitive decline and dementia, but the underlying mechanisms are largely unknown. We investigated the associations of cumulative BP exposure with hippocampal subfield volume and cognitive function and determined whether hippocampal subfield atrophy mediates the association between cumulative BP exposure and cognitive decline.
Methods: Between December 2020 and March 2023, participants were prospectively included from the Kailuan study.