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Adequate supplies of healthy foods available in each country are a necessary but not sufficient condition for adequate intake by each individual. This study provides complete Nutrient Balance Sheets that account for all plant-based and animal-sourced food flows from farm production through trade to non-food uses and waste in 173 countries from 1961 to 2018. We track 36 bioactive compounds in all farm commodities recorded by the Food and Agriculture Organization of the United Nations, accounting for nutrient-specific losses in processing and cooking as well as bioavailability. We compare supply to requirements given each country's age-sex distribution and find that the adequacy of food supplies has increased but often remains below total needs, with even faster rise in energy levels and lower density of some nutrients per calorie. We use this nutrient accounting to show how gaps could be filled, either from food production and trade or from selected biofortification, fortification and supplementation scenarios for nutrients of concern such as vitamin A, iron and zinc.
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http://dx.doi.org/10.1038/s43016-022-00585-w | DOI Listing |
Phytochemistry
September 2025
State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; Yunnan Characteristic Plant Extraction Laboratory Co. Ltd, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Educa
Alstoniaschines A‒I (1‒9), nine previously alkaloids sharing five different skeletons were obtained from the leaves of Alstonia scholaris. The structures and absolute configurations were established by their extensive spectroscopic data analyses, including NMR, HRESIMS, X-ray crystallography data, and theoretical ECD calculations. Compounds 1, 2, 3, and 9 exerted significant protective effect against oxidative stress and inflammatory damage of podocytes induced by high glucose, manifesting as the increase of superoxide dismutase, catalase, glutathione peroxidase, alongside the reductions of malondialdehyde, nitric oxide, lactate dehydrogenase.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Institute of Materia Medica, Jinzhou Medical University, Jinzhou, Liaoning 121001, China. Electronic address:
Ethnopharmacology Relevance: Tangningtongluo Tablets (TNTL), a novel Miao ethnic medicine for treating type 2 diabetes mellitus (T2DM) and its complications. However, its potential bioactive components and the pharmacological mechanisms underlying its therapeutic effects remain unclear.
Aim Of The Study: This study aims to preliminarily explore the protective effects of TNTL and its active components on pancreatic cells via the PI3K/Akt/FoxO1 pathway and further investigate the underlying mechanisms.
Comput Biol Chem
September 2025
Department of Biotechnology, Deenbandhu Chhotu Ram University of Science & Technology, Murthal, Haryana 131039, India. Electronic address:
Lentinula edodes (shiitake mushroom) is a widely cultivated edible and medicinal fungus, valued for its bioactive compounds. While East Asian strains have been well studied, Indian populations remain under-characterized. This study explores the genetic and functional diversity of five Indian-origin L.
View Article and Find Full Text PDFNutr Rev
September 2025
Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Pomegranate (Punica granatum L) is a rich source of bioactive compounds, including punicalagin, ellagic acid, anthocyanins, and urolithins, which contribute to its broad pharmacological potential. This review summarizes evidence from in vitro and in vivo experiments, as well as clinical studies, highlighting pomegranate's therapeutic effects in inflammation, metabolic disorders, cancer, cardiovascular disease, neurodegeneration, microbial infections, and skin conditions. Mechanistic insights show modulation of pathways such as nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK), alpha serine/threonine-protein kinase (AKT1), and nuclear factor erythroid 2-related factor 2 (Nrf2).
View Article and Find Full Text PDFChem Biodivers
September 2025
Instituto De Química, Universidade Federal de Mato Grosso Do Sul, Campo Grande, Brazil.
Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves.
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