relieves weaning diarrhea improving gut microbiota and redox homeostasis using a piglet model.

Weaning stress commonly damages the intestinal barrier of mammals, resulting in gut microbiota dysbiosis, intestinal illness, and even severe diarrhea. Probiotics are used as a nutritional strategy to promote the health of humans and animals and the gut microbiota balance. Here was applied as a probiotic supplement to a weaned piglet model to investigate its impacts on growth performance, antioxidant capacity, inflammation response, and intestinal health. Supplemental 1 g kg 10 cfu g 13611 significantly decreased the feed conversion ratio (FCR), alleviated diarrhea, improved the apparent total tract digestibility of neutral detergent fiber (NDF) and gross energy (GE), increased the concentration of total antioxidant capacity (T-AOC) and catalase (CAT) in serum, and decreased the concentration of malondialdehyde (MDA) and pro-inflammatory cytokines such as interleukin-1β (IL-1β) in serum. Importantly, supplementation of 13611 also improved the gut microbiota, decreasing the relative abundance of , enriching the relative abundances of and , and increasing the relative abundances of two species of ( and ). In conclusion, 13611 could effectively promote growth performance and alleviate diarrhea in a model of weaned piglets, which may be related to improved antioxidant activity, anti-inflammatory response, and alteration in the structure of the gut microbiota.