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Article Abstract
Borane-amines undergo exclusive monoacetoxylation to trifluoroacetoxyborane-amines (TFAB-amines), which serve as chemoselective reagents for direct reductive amination of aldehydes and ketones. TFABNEt has been established as mild and highly selective compared to widely-used NaBHCN and Na(AcO)BH, even at higher temperatures with challenging substrates. A mechanism involving polyaminoborane formed dehydroacetoxylation of TFABNH has been described.
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