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Cocaine use is rising in persons ≥50 years old and in black and socioeconomically disadvantaged communities. Cocaine-induced bowel ischemia and gastrointestinal injury are deadly findings that have been previously described in the literature. In this report, we present a case of small bowel ischemia, perforation, and upper gastrointestinal hemorrhage co-occurring in a 62-year-old incarcerated male with a 15-year history of cocaine use. The patient presented from jail, peritonitic in septic shock, and was promptly taken for emergent surgical exploration. He was found to have massive fecal peritonitis secondary to full-thickness ischemia and perforation of the jejunum and ileum. Immediately postoperatively, the patient developed a large volume of hemorrhage from multiple gastric and duodenal ulcers refractory to endoscopic intervention, ultimately requiring emergent embolization of the gastroduodenal artery. His course was further complicated by severe septic shock with a blunted response to catecholamine vasopressors. Early recognition and aggressive treatment of the gastrointestinal complications and the unique critical care challenges associated with cocaine use facilitated this patient's eventual full recovery.
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http://dx.doi.org/10.7759/cureus.28538 | DOI Listing |
Langenbecks Arch Surg
September 2025
Department of Surgery (A), Medical Faculty, Heinrich-Heine-University, University Hospital Duesseldorf, Duesseldorf, Germany.
Introduction: Remote ischaemic preconditioning (RIPC) which consists of repeated brief episodes of non-lethal limb ischaemia is associated with organ protection and improved clinical outcomes through complex pathophysiological pathways. The aim of this meta-analysis was to evaluate the postoperative effects of RIPC in bowel recovery and surgical morbidity after colorectal surgery.
Methods: In strict adherence to the PRISMA guidelines, a systematic literature search was performed for studies comparing the postoperative effect RIPC in colorectal surgery.
Ann Afr Med
September 2025
Department of Medical Gastroenterology, Dr. D. Y. Patil Vidyapeeth, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India.
Solitary rectal ulcer syndrome (SRUS) is an uncommon, benign condition that presents with a wide range of symptoms mimicking other pathological conditions, often leading to misdiagnosis and delays in treatment. A 60-year-old male patient was diagnosed with SRUS with rectal stricture with the help of colonoscopy, anorectal manometry, magnetic resonance defecography, and histopathological examination. He was managed with high-fiber diet, laxatives, biofeedback therapy, argon plasma coagulation, and stricture dilatation, which effectively alleviated the patient's condition.
View Article and Find Full Text PDFAm J Case Rep
September 2025
Department of Medicine, Infectious Disease Section, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
BACKGROUND Gastrointestinal mucormycosis is an underrecognized and underreported fungal infection with a high mortality rate. Diagnosis is often confounded by a non-specific constellation of signs and symptoms. We present a case of neutropenic colitis and ileocecal perforation secondary to gastrointestinal mucormycosis.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
September 2025
Department of Anesthesiology, Qianjiang Maternal and Child Health and Family Planning Service Centre, Qianjiang, Hubei, China.
Acute lung injury (ALI) is a major contributor to the high morbidity and mortality associated with intestinal ischemia-reperfusion (II/R). Despite its severity, current clinical management of ALI remains limited to supportive care without addressing the cause of the disease, underscoring the urgent need to investigate the underlying mechanism and develop targeted therapies. In this study, we employed both in vitro and in vivo models to explore ALI in the setting of II/R.
View Article and Find Full Text PDFBr J Nurs
September 2025
Professor, Department of Digestive Diseases, Transplantation and General Surgery, Copenhagen University Hospital Rigshospitalet/Department of Clinical Medicine, University of Copenhagen, Denmark.
Introduction: Approximately 1 million people live with ileostomies and rely on stoma bags in their daily lives. They do not have access to alternative products. To address alternatives, InterPoc™, an absorbent intestinal tampon, has been developed.
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