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http://dx.doi.org/10.1016/j.jinf.2022.09.005 | DOI Listing |
Ear Hear
September 2025
Department of Otorhinolaryngology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands.
Objectives: Alexithymia is characterized by difficulties in identifying and describing one's own emotions. Alexithymia has previously been associated with deficits in the processing of emotional information at both behavioral and neurobiological levels, and some studies have shown elevated levels of alexithymic traits in adults with hearing loss. This explorative study investigated alexithymia in young and adolescent school-age children with hearing aids in relation to (1) a sample of age-matched children with normal hearing, (2) age, (3) hearing thresholds, and (4) vocal emotion recognition.
View Article and Find Full Text PDFJ Acoust Soc Am
September 2025
Medizinische Physik and Cluster of Excellence "Hearing4all, " Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Processing delays can negatively affect listening experience, especially in cases where the (processed) delayed sound interferes with an un-delayed (or direct) sound component, as it is the case for (open-fit) hearing devices. In this study, psychometric functions for delay perception in individual frequency bands were measured. Also, it was assessed how noticeability adds up across frequency bands for frequency-dependent processing delays.
View Article and Find Full Text PDFLangmuir
September 2025
Department of Mechanical and Industrial Engineering, Montana State University, Bozeman, Montana 59717, United States.
Global challenges posed by freshwater scarcity and the water-energy nexus drive demand for novel macromolecular design of tailored nanostructures endowed with a variety of hydrophilic and hydrophobic features. Offering potential to meet this demand, metal-organic framework (MOF) materials are synthesized from coordinated formations that create versatile reticular structures with variable water adsorption affinities. However, advances in the fundamental understanding of water interactions within these structures are impeded by the failure of classical analyses to identify mechanisms of interaction, connect fundamental isotherm types, and provide appropriate benchmarks for assessment.
View Article and Find Full Text PDFMicrobiol Spectr
September 2025
Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Unlabelled: Severe acute pancreatitis (SAP) is characterized by systemic inflammation and intestinal barrier dysfunction and is often associated with gut microbiota dysbiosis. Rifaximin, a gut-specific non-absorbable antibiotic, is known to modulate the gut microbiota. Here, we investigated rifaximin's effects and mechanisms in SAP using murine models and a single-center, open-label, randomized controlled trial (Chinese Clinical Trial Registry: ChiCTR2100049794).
View Article and Find Full Text PDFRSC Med Chem
August 2025
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University 4.5 Km the Ring Road Ismailia 41522 Egypt.
Protein kinases are central regulators of cell signaling and play pivotal roles in a wide array of diseases, most notably cancer and autoimmune disorders. The clinical success of kinase inhibitors-such as imatinib and osimertinib-has firmly established kinases as valuable drug targets. However, the development of selective, potent inhibitors remains challenging due to the conserved nature of the ATP-binding site, off-target effects, resistance mutations, and patient-specific variability.
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