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Introduction: Detection of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been critical to support and management of the COVID-19 pandemic. Point of care testing (POCT) for SARS-CoV-2 has been a widely used tool for detection of SARS-CoV-2.
Areas Covered: POCT nucleic acid amplification tests (NAATs) and rapid antigen tests (RATs) have been the most readily used POCT for SARS-CoV-2. Here, current knowledge on the utility of POCT NAATs and RATs for SARS-CoV-2 are reviewed and discussed alongside aspects of quality assurance factors that must be considered for successful and safe implementation of POCT.
Expert Opinion: Use cases for implementation of POCT must be evidence based, regardless of the test used. A quality assurance framework must be in place to ensure accuracy and safety of POCT.
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http://dx.doi.org/10.1080/14737159.2022.2122712 | DOI Listing |
JMIR Res Protoc
September 2025
Institute of Higher Education and Research in Healthcare, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Background: In pediatric intensive care units, pain, sedation, delirium, and iatrogenic withdrawal syndrome (IWS) must be managed as interrelated conditions. Although clinical practice guidelines (CPGs) exist, new evidence needs to be incorporated, gaps in recommendations addressed, and recommendations adapted to the European context.
Objective: This protocol describes the development of the first patient- and family-informed European guideline for managing pain, sedation, delirium, and IWS by the European Society of Paediatric and Neonatal Intensive Care.
J Ultrasound Med
September 2025
Harvard Medical School, Boston, Massachusetts, USA.
Acta Cardiol
September 2025
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Uric acid to HDL ratio (UHR) is a new measure of inflammation that has been widely used to study cardiovascular disease relationships. The aim of this study was to investigate the relationship between uric acid to HDL ratio and hypertension. We found that UHR was positively associated with hypertension prevalence in a nationally representative sample of U.
View Article and Find Full Text PDFJ Intensive Care Med
September 2025
Medical Intensive Care Unit, 108 Military Central Hospital, Hanoi, Vietnam.
Background: Bedside ultrasound is increasingly utilized to assess muscle mass in critically ill patients, providing a noninvasive and real-time tool for early risk stratification. Muscle wasting is known to be associated with adverse outcomes in septic shock, but its prognostic value using ultrasound in this population remains underexplored. This study aimed to investigate the association between changes in rectus femoris cross-sectional area (CSA), assessed by bedside ultrasound, and 28-day mortality in patients with septic shock.
View Article and Find Full Text PDFLangmuir
September 2025
Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi 110016, India.
The study addresses the critical issue of sepsis diagnosis, a life-threatening condition triggered by the body's immune response to infection that leads to mortality. Current diagnostic methods rely on the time-consuming assessment of multiple biomarkers by a series of tests, leading to delayed treatment. Here, we report a platform for developing a point-of-care (POC) device utilizing electrochemical immunosensors for the dual and rapid detection of sepsis biomarkers: Procalcitonin (PCT), Interleukin-6 (IL-6), and C-reactive protein (CRP) as host markers and lipopolysaccharide (LPS) as a pathogen marker.
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