A Rapid Electrochemical Immunosensor Platform for the Sepsis-Associated Host and Pathogen Marker Dual Detection.

The study addresses the critical issue of sepsis diagnosis, a life-threatening condition triggered by the body's immune response to infection that leads to mortality. Current diagnostic methods rely on the time-consuming assessment of multiple biomarkers by a series of tests, leading to delayed treatment. Here, we report a platform for developing a point-of-care (POC) device utilizing electrochemical immunosensors for the dual and rapid detection of sepsis biomarkers: Procalcitonin (PCT), Interleukin-6 (IL-6), and C-reactive protein (CRP) as host markers and lipopolysaccharide (LPS) as a pathogen marker.

Maternal Dyslipidemia and Its Association With Preterm Birth and Other Adverse Perinatal Outcomes.

Background The existing literature has reported a conflicting relationship between maternal dyslipidemia and preterm birth. No significant research has been performed to determine the association between maternal dyslipidemia and low birth weight (LBW), neonatal intensive care unit (NICU) stay, need for neonatal phototherapy, need for assisted ventilation, and stillbirths. This study aims to determine the association between maternal dyslipidemia and preterm births and other adverse perinatal outcomes.

Electrochemical remediation of microplastics: Progress and prospects in water treatment.

Plastic pollution has emerged as a critical global concern, with microplastics (MPs)-defined as plastic particles smaller than 5 mm-posing serious threats to both environmental and human health. In 2019, global plastic production reached approximately 259 million tons, and is projected to rise to 500 million tons by 2025. By 2060, MPs are expected to account for a significant share of accumulated plastic waste, potentially reaching 1.

Electrochemical Biosensors for Sepsis Detection in Liver Cirrhosis: Advances and Insights.

Liver cirrhosis, a progressive disease caused by chronic liver conditions, significantly increases the risk of sepsis due to immune dysfunction. The overlapping symptoms of cirrhosis and sepsis make early diagnosis particularly challenging, emphasizing the need for reliable biomarker diagnostic tools. Conventional methods are slow and result in delayed treatment, deteriorating liver function in cirrhotic patients over time.

Bioinspired Silica Nanoparticles for Enhanced Adhesion and Retention of Biomolecules: A Sustainable and Green Strategy for Disease Management.

The growing significance of sustainable agriculture is underscored by the escalating global demand for food and environmental degradation. Continuously adapting plant pathogens presents a significant challenge to sustainable agriculture, leading to substantial global crop losses. is widely distributed and poses a menace to a diverse range of economically important crops.

Characterization of Phenolics and Influence of Phytic Acid Content on Iron and Zinc Bioaccessibility in Chapati Prepared From Diverse Pearl Millet Genotypes.

This study investigates the influence of phytic acid on Fe and Zn bioaccessibility and impact of phenolics on free radical scavenging activity in 13 diverse pearl millet (PM) genotypes. Forty-three phenolic compounds were identified using UPLC-(ESI)-QToF-MS. Free (173.

Role of MSX1 in the development of non-syndromic clefts in the sub-Himalayan region of India.

Non-syndromic cleft lip and palate (NSCL/P) is a prevalent congenital anomaly influenced by genetic and environmental factors. The role of the MSX1 gene in NSCL/P has been explored in various populations, with conflicting results. This study investigates the association between MSX1 single nucleotide polymorphisms (SNPs) rs11726039 and rs3821949 and NSCL/P in a sub-Himalayan population of India.

Image-guided targeting of mitochondrial metabolism sensitizes pediatric malignant rhabdoid tumors to low-dose radiotherapy.

Tumor hypoxia leads to radioresistance and markedly worse clinical outcomes for pediatric malignant rhabdoid tumors (MRTs). Our transcriptomics and bioenergetic profiling data reveal that mitochondrial oxidative phosphorylation is a metabolic vulnerability of MRT and can be exploited to overcome consumptive hypoxia by repurposing an FDA-approved antimalarial drug, atovaquone (AVO). We then establish the utility of oxygen-enhanced-multispectral optoacoustic tomography, a label-free, ionizing radiation-free imaging modality, to visualize and quantify spatiotemporal changes in tumor hypoxia in response to AVO.

Pharmacological profiling in CLL patients during pirtobrutinib therapy and disease progression.

Pirtobrutinib is a reversible Bruton's tyrosine kinase (BTK) inhibitor that has shown efficacy for patients with chronic lymphocytic leukemia (CLL) in BRUIN trial. These patients were previously treated with covalent BTK inhibitor (cBTKi) and either discontinued cBTKi or had disease progression during therapy. As a result, some patients had wild-type BTK while others had mutant BTK (mostly C481 site where cBTKi binds).

Expanding the chemical space of flavins with pentacyclic architecture.

Inspired by the prominent redox and optical properties of natural flavins, synthetic flavins have found broad applications in organic, photochemical, and biochemical research. Tailoring these properties of flavins, however, remains a challenge. In this work, we present three pentacyclic flavins (C-PF, O-PF, and S-PF) that leverage a strategic molecular design to modify the flavin's electronic structure.

Genetic Origin of Osseous Metaplasia of the Endometrium: A Case Series.

Osseous metaplasia of the endometrium is the presence of mature and immature bone tissue inside the endometrial cavity. We present a case series of three women who presented with various complaints of vaginal discharge and menstrual abnormalities. On hysteroscopy, bone fragments were extracted.

"Vitamin D Insufficiency in the Cleft Population of the Sub-Himalayan Region".

IntroductionChildren with clefts have been shown to have various nutrient deficiencies including protein energy malnutrition but the levels of vitamin D as compared to normal population have seldom been researched.Materials and MethodsSerum levels of Vitamin D in children with clefts (12 years and less), belonging to the Sub-Himalayan and Gangetic Plain regions were compared with age matched normal population using non-parametric tests. Bivariate Logistic regression for estimation of odds ratio for cleft versus control were performed for risk estimation of vitamin D insufficiency (less than 30 ng/mL).

Medicinal plant ashwagandha in hydroponics: Pioneering greywater remediation using response surface methodology along with plants' physiological and phytochemical attributes for sustainable resource recovery.

This study aimed to investigate greywater treatment through hydroponically growing ashwagandha, often referred to as "Indian Ginseng," which is rich in secondary metabolites and bioactive compounds that enhance its medicinal properties. The research examines the effect of input parameters, such as initial chemical oxygen demand (300-1500 mg/L), phosphate (0-120 mg/L), and nitrate (15-75 mg/L) and their optimization utilizing response surface methodology (RSM) with central composite design (CCD). The interactive effects are analysed with model fit through analysis of variance.

Valorizing Banana Peel Waste into Mesoporous Biogenic Nanosilica and Novel Nano-biofertilizer Formulation Thereof via Nano-biopriming Inspired Tripartite Interaction Studies.

The present study attempts to valorize banana peel waste (BPW) into high-value precipitated nanosilica-based agri-input. XRD analysis revealed smaller-sized biogenic nanosilica (BNS) with an increase (without heating) or decrease (with heating) in the duration of acid pretreatment during the pre-calcination step. The highest BNS yield was recorded in post-calcinated BPW ash involving simultaneous acid and heat treatment (1 h) (SA-3).

Microgel-based modular 3D microfluidic cell culture platforms.

The combination of 3D cell culture and microfluidic technology has emerged as a powerful approach in biomedical engineering. It offers a more physiologically relevant model compared to traditional 2D cell cultures by allowing the assembly of micro-sized cellular structures, known as microgels. These microgels can be prepared and fabricated to mimic the characteristics of an ECM.

1,4-Bis(2-hydroxyethyl)piperazine-derived water-dispersible and antibacterial polyurethane coatings for medical catheters.

To prolong usage and mitigate infections associated with bacterial colonization on medical catheters, the development of water-dispersible polyurethane (PU) coatings with bactericidal properties is desirable. With this objective, we have formulated polyurethane coatings that exhibit both antibacterial activity and water dispersibility. A piperazine-based diol, 1,4-bis(2-hydroxyethyl)piperazine (HEPZ), was synthesized and used as a chain extender in PU synthesis.

Ultrasound stimulated piezoelectric antibacterial silk composite films guiding differentiation of mesenchymal stem cells.

Smart materials for tissue engineering have been in extensive use for few decades now. This work delves into the exploration of ultrasound-stimulated piezoelectric and antibacterial silk-based composite films as a pioneering strategy to guide the differentiation of human mesenchymal stem cells into osteogenic lineage without the application of any exogenous growth factors. The study evaluates the biocompatibility and antibacterial attributes of these films, which incorporates Barium Titanate nanoparticles (BTNPs) along with Zinc Oxide nanoparticles for obtaining high piezo modulated stimuli response and antibacterial properties.

Miniaturized Liver Disease Mimics to Gain Insights into MMP Expression during Disease Progression.

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions, ranging from hepatic steatosis to steatohepatitis, fibrosis, and severe outcomes such as cirrhosis or cancer. The progression from hepatic steatosis to fibrosis involves significant extracellular matrix (ECM) remodeling, characterized by increased collagen deposition and cross-linking of ECM proteins, causing increased tissue stiffness and altered MMP expression patterns. Dysregulated MMP expression and extracellular acidosis are key contributors to NAFLD progression.

Osseous metaplasia of the endometrium presenting as haematometra: a rare presentation.

Osseous metaplasia of the endometrium is a rare condition involving the bone tissue in the endometrial cavity. Its presence along with haematometra is an infrequent condition and is not reported until now. We present a case of a woman in her mid-30s with primary infertility and secondary amenorrhoea.

Folic acid-targeted redox responsive polylactic acid-based nanoparticles co-delivering pirarubicin and salinomycin suppress breast cancer tumor growth .

Targeted cancer therapy using nanocarriers has emerged as a promising solution to the majority of drawbacks associated with conventional chemotherapy. The present research work describes the development of folic acid (FA)-targeted redox responsive [S-(PLA--PEG-CONH)] polymeric nanoparticles for the co-delivery of pirarubicin (Pira) and salinomycin (Sal). The nanoparticles' redox responsiveness arises from embedded disulfide bonds within the polymer, which gradually break in response to high GSH levels in tumors, enabling sustained drug release.

Mathematical modeling and kinetics of batch and continuous electro-catalytic oxidation of pharmaceutical-contaminated wastewater.

An accurate yet simple model is the key to the design and control of intricate electro-catalytic oxidation of pharmaceutical contaminated wastewater. For both batch and unsteady-state continuous flow stirred tank reactors (CSTR), batch reactor models have been used earlier. Further, these models do not correlate rate to the operating conditions, and consider pseudo-first/second-order kinetics.