98%
921
2 minutes
20
The number of lung transplant procedures performed internationally is increasing but the donor organ pool is insufficient to meet demand and waiting list mortality is unacceptably high. As survival rates for patients with acute respiratory distress syndrome managed on extracorporeal life support (ECLS) have steadily improved, a potential role for ECLS to support critically ill patients awaiting a donor organ match has emerged. We explore the rapidly evolving landscape of ECLS as a bridge to lung transplantation with review of the patient selection criteria, predictors of survival, modes of pre and peri-transplant support, and the importance of a holistic multidisciplinary approach to care. Finally, we consider innovations that are envisaged to increase the accessibility, safety, and effectiveness of ECLS delivery for future lung transplant candidates.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.healun.2022.06.004 | DOI Listing |
J Surg Res
September 2025
Pediatric Surgery Division, Department of Surgery, University of Alabama-Birmingham, Children's of Alabama, Birmingham, Alabama.
Introduction: Application of extracorporeal life support during cardiac arrest is termed extracorporeal cardiopulmonary resuscitation (eCPR). Mortality in pediatric patients undergoing eCPR for noncardiac conditions remains high and factors influencing survival are not well-defined. We hypothesized that eCPR survivors are more likely to have less severe electrolyte derangements prior to cannulation than nonsurvivors.
View Article and Find Full Text PDFASAIO J
September 2025
Division of Developmental Pediatrics, Department of Pediatrics, University of Alberta and Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada.
This referral center's prospective inception-cohort study from 1989 to 2000 (Era 1) and 2000 to 2022 (Era 2) included 232 consecutive children having neonatal respiratory extracorporeal membrane oxygenation (ECMO). Kindergarten-age outcomes determined in 137/139 (95.8%) survivors were Wechsler Preschool and Primary Scales of Intelligence, Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI), and sensorimotor disability, with optimal outcome defined as scores greater than or equal to 80 and without disability.
View Article and Find Full Text PDFBrain Res Bull
September 2025
Academy of Medical Engineering and Translation Medicine, Tianjin University, Tianjin 300072, China.
Brain tumors are one of the most dangerous cancers with serious effects on human health. The primary treatment approach involves a combination of surgery, supplemented by postoperative radiotherapy. The growth pattern of malignant tumor is typically infiltrative, posing a challenge in visually distinguishing the tumor from the surrounding normal brain tissue during surgery.
View Article and Find Full Text PDFJ Cardiothorac Vasc Anesth
August 2025
Department of Pediatrics, Section of Critical Care, Baylor College of Medicine, Houston, TX.
Objective: To describe the characteristics and outcomes of patients with COVID-19 infection with acute or chronic pulmonary hypertension (PH) supported by extracorporeal membrane oxygenation (ECMO). It was hypothesized that patients with acute or chronic PH supported by ECMO would have higher mortality rates compared to those without a diagnosis of PH.
Design: A retrospective analysis of the Extracorporeal Life Support Organization registry.
Cureus
August 2025
Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center, Kobe, JPN.
Objective This study aimed to evaluate the influence of public assistance on patients with out-of-hospital cardiac arrest (OHCA) who received extracorporeal cardiopulmonary resuscitation (ECPR) in Japan. Methods We conducted a secondary analysis of data from the SAVE-J II study, a retrospective, multicenter registry study involving 36 participating institutions in Japan. Patients with cardiac arrest who received ECPR were divided into two groups, depending on whether or not they had received public assistance.
View Article and Find Full Text PDF