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The presence of obstacles is intuitively expected to hinder the diffusive transport of active particles. However, for chiral active particles, a low density of obstacles near a surface can enhance their diffusive behavior. Here, we study numerically the role that disorder plays in determining the transport dynamics of chiral active particles on surfaces with obstacles. We consider different densities of regularly spaced obstacles and distinct types of disorder: noise in the dynamics of the particle, quenched noise in the positions of the obstacles as well as obstacle size polydispersity. We show that, depending on the type and strength of the disorder, the presence of obstacles can either enhance or hinder transport, and discuss implications for the control of active transport in disordered media.
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http://dx.doi.org/10.1039/d2sm00694d | DOI Listing |
Soft Matter
September 2025
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
We introduce a theoretical and computational framework for extracting the pressure equation of state (EoS) of an active suspension from its steady-state sedimentation profile. As EoSs are prerequisites for many theories in active matter, determining how pressure depends on key parameters such as density, activity, and interparticle interactions is essential to make quantitative predictions relevant to materials design and engineering applications. Focusing on the one-dimensional active Brownian particle (1D-ABP) model, we show that the pressure measured in a homogeneous periodic system can be recovered from the spatial profiles established in sedimentation equilibrium.
View Article and Find Full Text PDFCurr Cancer Drug Targets
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Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Menoufia, Egypt.
Introduction: Breast cancer is the most common malignancy among women and the second leading cause of cancer-related deaths worldwide. Resveratrol, a polyphenolic stilbene derivative found in grapes, red wine, and other plants, possesses anti-cancer properties. Various studies have reported the potential of different nanomaterials to act as radiosensitizers against tumor cells.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR C
Silicon dioxide nanoparticles (SiO NPs) are a novel material with a wide range of applications whose cumulative effects in the body pose certain health risks. The types of gastric injuries caused by different-sized SiO NPs and their mechanisms, however, remain unclear. Based on this, we established a mouse subchronic exposure model (10 mg/kg/d, 21 consecutive days of tube-feeding) with different SiO NP sizes (50, 300, and 1000 nm) in conjunction with in vitro MC9 and BMMCs models (160 μg/mL exposure for 24 h) to explore the gastric injury mechanisms.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
State Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Detection of Veterinary Drug Residues and Illegal Additives of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. Electronic address: haiyang
Background: Aflatoxin B1 (AFB1) stands among the most toxic naturally occurring substances, with its acute toxicity characterized by the induction of acute hepatic necrosis, hemorrhage, and even fatal outcomes, thereby posing a profound threat to human health. Contamination of AFB1 in food commodities can arise at multiple stages throughout the production cycle, including cultivation, storage, and processing. This contamination cascade permeates the entire food supply chain, encompassing primary agricultural products as well as a diverse range of processed food items.
View Article and Find Full Text PDFJ Pharm Sci
September 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Bacterial burn wound infections can disrupt the natural wound-healing process, leading to life-threatening diseases. This study aimed to investigate the use of glycerosomes as a novel system for the topical delivery of cefoperazone to promote its burn wound healing action. Cefoperazone-loaded glycerosomes (CEFO-GLY) were optimized using a 2 full-factorial design and prepared via the thin film hydration method.
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