Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: To investigate the altered functional connectivity (FC) of the cerebral hemispheres in patients with morbid obesity (MO) with meibomian gland dysfunction (MGD) by voxel-mirrored homotopic connectivity (VMHC).
Methods: Patients and matched healthy controls (HCs) were recruited, and all subjects underwent functional resonance magnetic imaging (fMRI), and VMHC results were processed statistically to assess the differences in FC in different brain regions between the two groups. We further used ROC curves to evaluate the diagnostic value of these differences. We also used Pearson's correlation analysis to explore the relationship between changes in VMHC values in specific brain regions, visual acuity, and Mini-Mental State Examination (MMSE) score.
Conclusions: Patients with morbid obesity and MGD had abnormal FC in the cerebral hemispheres in several specific brain areas, which were mainly concentrated in pathways related to vision and perception and may correlate to some extent with the clinical presentations of the patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9405716 | PMC |
| http://dx.doi.org/10.3390/brainsci12081078 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.
Hum Brain Mapp
September 2025
Department of Social Psychology and Quantitative Psychology, University of Barcelona, Barcelona, Spain.
Understanding functional brain development during childhood and adolescence is essential for identifying typical neurodevelopmental trajectories. While resting-state fMRI (rs-fMRI) has become a key tool in developmental neuroscience, few studies have jointly examined multiple functional metrics to comprehensively characterize typical brain maturation across youth. We analyzed rs-fMRI data from 395 neurotypical participants aged 6-20 years from the ABIDE I and II datasets.
View Article and Find Full Text PDFNeuroimaging and biological markers of different paretic hand outcomes after stroke.
J Neuroeng Rehabil
July 2025
Rehabilitation Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Background: Hand dysfunction significantly affects independence after stroke, with outcomes varying across individuals. Exploring biomarkers associated with the paretic hand can improve the prognosis and guide personalized rehabilitation. However, whether biomarkers derived from resting-state fMRI (rs-fMRI) can effectively classify and predict different hand outcomes and their biological mechanisms remain unclear.
View Article and Find Full Text PDFDisrupted resting-state interhemispheric functional connectivity in patients with first-episode moyamoya disease.
Sci Rep
July 2025
Department of Psychology and Sleep Medicine, the Second Affiliated Hospital of Anhui Medical University, 230022, Hefei, China.
Moyamoya disease (MMD) has been reported to be associated with a wide range of structural and functional abnormalities of bilateral hemispheres. However, whether the interhemisphere functional connectivity (FC) of MMD patients is altered and its relationship with cognitive impairments still remain unclear. A total of 20 patients with MMD and 25 healthy subjects were included, matched based on age, sex, and level of education.
View Article and Find Full Text PDFMultimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.
BMC Psychiatry
July 2025
Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Background: Major depressive disorder (MDD) affects over 300 million people globally, with sleep disorder (SD) being a common symptom. However, the neural mechanisms underlying this comorbidity remain poorly understood. Specifically, the role of interhemispheric functional connectivity, measured via voxel-mirrored homotopic connectivity (VMHC), in MDD with or without SD has not been systematically explored.
View Article and Find Full Text PDFCorrelates of asymmetric venous drainage in resting state functional magnetic resonance imaging data.
Brain Res
October 2025
Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus Oldenburg, Universitätsmedizin Oldenburg, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany; Department of Diagnostic and Interventional Radiology, Medical Facu
Functional magnetic resonance imaging (fMRI) is a technique for indirectly measuring cerebral neural activity. It depends on the local cerebral vasculature and perfusion. It has thus been suggested that pathologies and normal variants of the cerebral vasculature can bias conclusions drawn from fMRI.
View Article and Find Full Text PDF