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http://dx.doi.org/10.1055/a-1899-8098 | DOI Listing |
Br J Ophthalmol
September 2025
Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Background: Persistent full-thickness macular holes (FTMHs) following primary surgery represent a therapeutic challenge. Various surgical treatment approaches have been proposed. This study evaluates anatomical and functional outcomes of a temporary silicone oil tamponade in persistent FTMH in a larger cohort.
View Article and Find Full Text PDFMacromol Rapid Commun
September 2025
Key Laboratory of Textile Science & Technology, College of Textiles, Ministry of Education, Donghua University, Shanghai, China.
Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Department of Orthopedics, Ningxiang Hospital of Traditional Chinese Medicine, Ningxiang, China.
Introduction: Delayed wound healing remains a significant clinical challenge under diabetic conditions, characterized by chronic inflammation and impaired angiogenesis. Traditional treatments show limited efficacy, highlighting the urgent need for innovative therapeutic approaches.
Methods: This study investigated the therapeutic potential of exosomes derived from subcutaneous adipocytes (Adipo-EVs) using a diabetic mouse model.
Mater Today Bio
October 2025
Radboud University Medical Center, Research Institute for Medical Innovation, Department of Medical BioSciences, Geert Grooteplein 28, 6525 GA, Nijmegen, the Netherlands.
Severe scarring is an inevitable consequence of large full-thickness skin wounds, often leading to long-term complications that affect patients' well-being and necessitate extended medical interventions. While autologous split-thickness skin grafts remain the clinical standard for wound treatment, they frequently result in contractures, excessive scarring, and the need for additional corrective procedures. To address these challenges, bioengineered skin substitutes capable of promoting efficient healing while reducing complications are highly desirable.
View Article and Find Full Text PDFJ Invest Dermatol
September 2025
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, DK. Electronic address:
Liquid chromatography-mass spectrometry (LC-MS) is an evolving tool for comprehensive proteomic analyses across tissues. Despite the widespread use of LC-MS in dermatology, full-thickness human skin remains challenging to analyse. The skin extracellular matrix (ECM) presents two major obstacles: the extensive crosslinking complicates protein extraction and the high abundance of ECM proteins can mask lower-abundance proteins, reducing identification numbers.
View Article and Find Full Text PDF