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Article Abstract
Results: Aqueous extract and essential oil reduced the viability of A549 cancer cells in a concentration-dependent manner. The lowest inhibitory concentrations (IC) for both samples of oleo-gum resin were 10 and 2.5 g/ml for 24 hours in A549 cell line, respectively. After treatment with extract and essential oil of oleo-gum resin, ROS increased significantly compared to the control group. Although changes in caspase-3 did not show a significant increase in extract, the caspase-3 was found to be increased after exposure to essential oil and caspase-9 was downregulated after exposure to essential oil. Also, exposure to essential oil of caused a reduction in MMP level.
Conclusion: Based on results, the cytotoxic effect of essential oil of can induce apoptosis toward A549 cell line via induction of oxidative stress, MMP depletion, and caspase-3 activation, which is independent to mitochondrial cytochrome c release and caspase-9 function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381248 | PMC |
| http://dx.doi.org/10.1155/2022/9725244 | DOI Listing |
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