Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s42255-022-00628-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
CLAW-MRM: omprehensive ipidomics utomation orkflow for ultiple eaction onitoring Using Large Language Models.
Anal Chem
September 2025
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.
Lipidomic profiling generates vast datasets, making manual annotation and trend interpretation complex and time-intensive. The structural and chemical diversity of the lipidome further complicates the analysis. While existing tools support targeted lipid identification, they often lack automated workflows and seamless integration with statistical and bioinformatics tools.
View Article and Find Full Text PDFDevelopment of a dual-channel analytical approach for diabetic biomarker discovery in blood via integrative metabolomics and lipidomics.
J Chromatogr A
August 2025
Graduate School, Tianjin Medical University, Tianjin, 300070, PR China; Mass Spectrometry Application Technology Laboratory, Tianjin Medical College, Tianjin, 300222, PR China. Electronic address:
Conventional metabolomics and lipidomics typically require separate sample preparations, which can introduce systematic bias and reduce throughput, thereby hindering comprehensive elucidation of diabetic metabolic networks. In this study, we exploited the pH-responsive behavior of ZrO₂-SiO₂ composite microspheres to establish the first single-sample, dual-channel solid-phase extraction (SPE) pretreatment method: under acidic conditions, Zr⁴⁺-PO₄³⁻ coordination selectively adsorbs phospholipids, whereas under basic conditions, NH₄⁺ competes to gently elute them. The flow-through and elution fractions are used for metabolomic and lipidomic analyses, respectively.
View Article and Find Full Text PDFLipid-dependent growth of Malassezia spp. in defined medium with single fatty acids.
FEMS Yeast Res
January 2025
Microbiology, Department of Biology, Utrecht University, 3584CH Utrecht, The Netherlands.
Details on fatty acid and lipid metabolism in Malassezia spp. are limited, amongst others, because efficient growth of Malassezia spp. in defined media with free fatty acids has not yet been described.
View Article and Find Full Text PDFComputationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics.
Nat Commun
August 2025
Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
Identifying carbon-carbon double bond (C=C) positions in complex lipids is essential for elucidating physiological and pathological processes. Currently, this is impossible in high-throughput analyses of native lipids without specialized instrumentation that compromises ion yields. Here, we demonstrate automated, chain-specific identification of C=C positions in complex lipids based on the retention time derived from routine reverse-phase chromatography tandem mass spectrometry (RPLC-MS/MS).
View Article and Find Full Text PDFA phospholipase effector of the type VI secretion system modulates plant reproduction.
mBio
August 2025
Department of Immunology and Microbiology, School of Life Sciences, Guangming Advanced Research Institute, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Phytobacteria play diverse roles in plant biology, ranging from promoting health to causing diseases that threaten global food security and the economy. In contrast to the extensive studies of phytopathogens targeting leaves and roots, their impact on plant reproductive processes has been largely overlooked. Here, we demonstrate that a bacterial effector TleB of the type VI secretion system in can modulate seed production of .
View Article and Find Full Text PDF