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http://dx.doi.org/10.12965/jer.2244250.125 | DOI Listing |
Virology
September 2025
Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany.
New SARS-CoV-2 variants continue to emerge and may cause new waves of COVID-19. Antibody evasion is a major driver of variant emergence but variants can also exhibit altered capacity to enter lung cells and to use ACE2 species orthologues for cell entry. Here, we assessed cell line tropism, usage of ACE2 orthologues and antibody evasion of variant MC.
View Article and Find Full Text PDFVaccine
September 2025
Pfizer Canada, Kirkland, Quebec, Canada.
The estimand framework as outlined in ICH E9(R1) has been extensively discussed and implemented in clinical trials of therapeutic products. However, there is limited literature on the application of the framework in preventive vaccine trials, which has many unique characteristics, including emphasis on estimating the per-protocol or "biological" effect. We provide a comprehensive review of the application of the framework to preventive vaccine trials evaluating clinical outcome and immunogenicity, focusing on commonly encountered intercurrent events including but not limited to: noncompliance with vaccination schedule and blood sampling window, infection not meeting protocol definition, death, and use of prohibited products.
View Article and Find Full Text PDFEcol Process
September 2025
Department of Environmental Systems Sciences, ETH Zürich, Zurich, Switzerland.
Background: Forest ecosystems are in the spotlight for their potential to mitigate anthropogenic carbon dioxide (CO) emissions through net photosynthesis. However, this mitigation potential can be counteracted by respiratory losses, e.g.
View Article and Find Full Text PDFMicromachines (Basel)
August 2025
School of Mechanical and Automotive Engineering, Xiamen University of Technology, Xiamen 361024, China.
For ultra-low-frequency vibration applications, this study focuses on a piezoelectric energy harvesting system with a spring mass system, utilizing magnetic plucking to up-convert the frequency. The proposed spring mass system includes a spring, a magnet mass with a guide rail, and a fixed pulley. The spring mass system responds to external ultra-low-frequency excitation and transfers the vibration to the piezoelectric cantilever beam through the magnets, achieving frequency up-conversion.
View Article and Find Full Text PDFBMC Public Health
August 2025
National Institute of Public Health, University of Southern Denmark, Studiestraede 6, Copenhagen, 1455, Denmark.
Background: Child overweight and obesity are major public health challenges associated with poor physical, psychological, and social health through life. This protocol describes the study design for the Bloom Study, an evaluation of a theory- and evidence-based intervention addressing infancy and toddlerhood (age 0-3 years) to promote healthy weight development among children in Denmark.
Methods: The Bloom intervention is evaluated through an open-label, two-arm, cluster-randomized wait-list control trial, with 22 municipalities randomly allocated to 11 intervention and 11 control municipalities.