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A new digital beam position and phase measurement (BPM) system was designed for the ion-Linac accelerator at the high intensity heavy ion accelerator facility. The fundamental and second harmonic signals are retrieved from the BPM electrodes to simultaneously calculate their respective beam positions and phases. All data acquisition and digital signal processing algorithm routines are performed in a field programmable gate array (FPGA). The position and phase information are obtained by using the in-phase and quadrature demodulation method. A practical and straightforward method is used to generate the second harmonic reference signal for processing the second harmonic beam signal. The reconfigurable filters are integrated into the FPGA to allow the measurement of short beam pulse length. The laboratory test results show that the achieved phase resolution is better than 0.2° and 0.03° when the input signal is -60 and -45 dBm, respectively. A position resolution better than 30 μm was achieved for an input power level of approximately -60 dBm, and it can reach 7 μm with the input power higher than -45 dBm. The entire execution time of the algorithm is accomplished within 3.4 µs, which provides a sufficient reaction time for the fast beam interlock signal to the machine protection system. The performance of this newly designed prototype BPM electronics was evaluated with the online proton beam.
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http://dx.doi.org/10.1063/5.0089407 | DOI Listing |
JCO Glob Oncol
May 2025
Grupo Oncoclínicas, São Paulo, Brazil.
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in developing countries, where access to early diagnosis, comprehensive care, and research infrastructure is limited. This article synthesizes the insights generated during a Fireside Chat convened by members of the Latin American Cooperative Oncology Group (LACOG)-Head and Neck and the Brazilian Group of Head and Neck Cancer (GBCP), with the participation of international expert Professor Hisham Mehanna. The discussion addressed key challenges and opportunities in clinical and translational research within resource-constrained settings.
View Article and Find Full Text PDFAdolescence is the phase of life during which most people become sexually active for the first time. It is essential for health care providers to assess the need for pregnancy prevention and provide comprehensive information on contraception, as well as sexually transmitted infection (STI) prevention. All currently available contraceptive methods are safe and effective for most adolescents.
View Article and Find Full Text PDFJB JS Open Access
September 2025
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Background: Lower extremity alignment in knee osteoarthritis (OA) is conventionally assessed using standing radiographs. However, symptoms often manifest during gait. Understanding dynamic alignment during gait may help characterize disease progression and inform treatment strategies.
View Article and Find Full Text PDFInt J Hyperthermia
December 2025
Department of Radiation Oncology Physics, University of Maryland, Baltimore, MD, USA.
Objective: To develop a deep learning method for fast and accurate prediction of Specific Absorption Rate (SAR) distributions in the human head to support real-time hyperthermia treatment planning (HTP) of brain cancer patients.
Approach: We propose an encoder-decoder neural network with cross-attention blocks to predict SAR maps from brain electrical properties, tumor 3D isocenter coordinates and microwave antenna phase settings. A dataset of 201 simulations was generated using finite-element modeling by varying tissue properties, tumor positions, and antenna phases within a human head model equipped with a three-ring phased-array applicator.
Methods
September 2025
Charles University, Faculty of Pharmacy in Hradec Kralove, Ak. Heyrovskeho 1203, Hradec Kralove 500 03, Czech Republic. Electronic address:
Chemically modified oligonucleotides (ONs) are essential tools in molecular biology, diagnostics, and therapeutics. Strain-promoted azide-alkyne cycloaddition (SPAAC) offers an efficient and bioorthogonal method for ON functionalization. While SPAAC reactions on solid-phase support provide distinct advantages, particularly for the incorporation of lipophilic labels, factors influencing their efficiency remain poorly characterized.
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