Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This study determined the extraction rates of indirubin in Indigo Naturalis by ethanol reflux extraction method and water extraction method. The pharmacodynamic study against cough induced by ammonia water in the mouse model and the cough induced by citric acid in the guinea pig model were performed to optimize the extraction process of the sovereign medicinal Indigo Naturalis and the whole prescription of Children's Qingfei Zhisou Syrup. The extraction rate of indirubin by the ethanol reflux method was 51.89%, and indirubin was not detected in the product of water extraction. Two samples of Children's Qingfei Zhisou Syrup prepared with different methods can prolong the incubation period of cough and suppress the frequency of coughs in pharmacodynamic experiments. In terms of prolonging the incubation period of cough, the two samples prepared with different methods had no significant difference. In terms of reducing the frequency of coughs, the high-dose Five kinds of ethanol extracts such as indigo naturalis and three kinds of water extracts such as gypsum had better effect against the citric acid-induced cough of guinea pigs than other samples(P<0.05). The extraction rate of indirubin in Children's Qingfei Zhisou Syrup sample prepared with ethanol was higher than that with water. The two samples of Children's Qingfei Zhisou Syrup prepared with the two methods showed good antitussive effects. The sample prepared with 5 ingredients(including Indigo Naturalis) extracted with ethanol and 3 ingredients(including Gypsum Fibrosum) extracted with water had better alleviation effect on the citric acid-induced cough of guinea pig than the whole water extract sample. In conclusion, the optimum extraction scheme is ethanol extraction for 5 ingredients including Indigo Naturalis in combination with water extraction for 3 ingredients including Gypsum Fibrosum, and the Children's Qingfei Zhisou Syrup produced in this manner has better antitussive efficacy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19540/j.cnki.cjcmm.20210806.301 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The efficacy of ophiopogonanone B in treating the cough in mice infected with .
Front Pharmacol
March 2025
College of Traditional Chinese Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China.
Introduction: Ophiopogonanone B is a potent component of Qinbai Qingfei-concentrated pills (Qinbai), a new traditional Chinese medicine developed by our hospital for the treatment of pneumonia in children. We aim to study how ophiopogonanone B influences the expression of transient receptor potential anchor protein 1 (TRPA1), substance P (SP), and calcitonin gene-related peptide (CGRP) to treat coughing in -infected mice.
Methods: Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was used to detect ophiopogonanone B.
Network pharmacology and molecular docking identified IL-6 as a critical target of Qing Yan He Ji against COVID-19.
Medicine (Baltimore)
November 2024
Department of Emergency, Jiangxi Provincial Children's Hospital, the Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China.
Since the coronavirus disease 2019 (COVID-19) outbreak, although have controlled, severe acute respiratory syndrome coronavirus 2 is constantly mutating and affects people's health. FDA has approved Paxlovid and Molnupiravir for COVID-19 treatment, however, they have not been approved for children under 12 years old. Therefore, it is urgent to explore new drugs for treating COVID-19 in children.
View Article and Find Full Text PDFNetwork pharmacology, molecular docking, and untargeted metabolomics reveal molecular mechanisms of multi-targets effects of Qingfei Tongluo Plaster improving respiratory syncytial virus pneumonia.
Chin Herb Med
October 2024
Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.
Objective: Qingfei Tongluo Plaster (QFP), an improved Chinese medicine hospital preparation, is an attractive treatment option due to its well clinical efficacy, convenience, economy, and patient compliance in the treatment of respiratory syncytial virus (RSV) pneumonia. The aim of this study was to investigate the efficacy mechanism of QFP on RSV rats from the perspective of alleviating lung inflammation and further explore the changes of serum metabolites and metabolic pathways in RSV rats under the influence of QFP.
Methods: This study used network pharmacological methods and molecular docking combined with molecular biology and metabolomics from multi-dimensional perspectives to screen and verify the therapeutic targets.
Qingfei Zhisou oral liquid alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression.
J Tradit Chin Med
October 2024
Institute of Basic Medical Sciences, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Article Synopsis
- The study investigates the effects of Qingfei Zhisou (QFZS) oral liquid on body temperature regulation and inflammatory factors in rats induced with fever.
- Researchers established a fever model using dry yeast and divided rats into different treatment groups to assess QFZS's impact on body temperature and inflammatory proteins.
- Results indicated that QFZS effectively lowered body temperature and reduced levels of inflammatory markers, suggesting its anti-inflammatory and anti-pyrexia actions may involve the metabolism of specific lipids and regulation of ion channels related to inflammation.
Yinqin Qingfei granules alleviate pneumonia via inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis.
Front Pharmacol
August 2024
Department of Pediatrics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Article Synopsis
- Pneumonia (MPP) is common in children, and the rising resistance of Mycoplasma pneumoniae (MP) to antibiotics highlights the need for new treatments, such as Yinqin Qingfei granules (YQQFG), a Chinese medicine with unclear mechanisms.
- Researchers identified 25 bioactive components in YQQFG that effectively target the NLRP3/Caspase-1/GSDMD pathway, which plays a role in inflammation caused by MP.
- Studies showed that YQQFG reduces harmful cytokines (IL-1β and IL-18) and MP exotoxin release, suggesting it could serve as a promising therapeutic option for pediatric pneumonia.