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Aim: To examine the longitudinal trajectory of intrinsic capacity over a 3-year period among long-term care recipients in Taiwan, its association with functional decline and the onset of severe dependency.
Methods: A total of 9448 individuals aged ≥50 years utilizing home and community-based long-term care services with complete data from three separate evaluations in Taiwan were included in the study. We carried out a latent class linear mixed model to identify heterogeneous patterns of intrinsic capacity over time, a mixed-effects model to investigate their impact on activities of daily living and a Kaplan-Meier analysis to examine the onset year of severe dependency among different intrinsic capacity classes.
Results: The results identified four classes sharing similar longitudinal the intrinsic capacity trajectories: "high-stable" (20.13%), "normal-stable" (40.58%), "sensory-dysfunction" (29.53%) and "all-dysfunction" (9.76%). Individuals with predisposing characteristics were associated with lower activities of daily living, with the exception of age and education level. In addition, the poor intrinsic capacity class (b from -16.94 to -6.61, P < 0.001) had a worse evolution in terms of activity of daily living scores, and was associated with an earlier onset of severe dependency in 2.5 years in the all-dysfunction class.
Conclusions: Heterogeneous patterns of intrinsic capacity that delay further functional decline are promising markers of function trajectories for a person-centered care approach in long-term care services. Targeting the needs of intrinsic capacity groups to prevent functional decline offer insights into: (i) strengthening function-centered care modalities to delay severe dependency as individuals get older; and (ii) validating regular monitoring intrinsic capacity as an early warning system to achieve healthy aging. Geriatr Gerontol Int 2022; 22: 516-522.
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http://dx.doi.org/10.1111/ggi.14391 | DOI Listing |
Mech Ageing Dev
September 2025
Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; Department of Medicine and Surgery, LUM University, Casamassima, Italy.
Age-related skeletal muscle decline is a major contributor to frailty, functional impairment, and loss of independence in advanced age. This process is characterized by selective atrophy of type II fibers, impaired excitation-contraction coupling, and reduced regenerative capacity. Emerging evidence implicates mitochondrial dysfunction as a central mechanism in the disruption of muscle homeostasis with age.
View Article and Find Full Text PDFComp Biochem Physiol Part D Genomics Proteomics
September 2025
Chinese PLA Centers for Disease Control and Prevention, Beijing, China. Electronic address:
The transmission of mosquito-borne diseases is intrinsically linked to mosquito blood-feeding behavior, yet the metabolic adaptations of the midgut microbiota in response to blood meals remain poorly understood. This study aimed to characterize the structural and functional changes in the midgut microbiota of Aedes albopictus following blood feeding and to elucidate their potential physiological implications. In this study, we employed 16S rRNA gene amplification coupled with PacBio Sequel II sequencing to characterize shifts in the midgut microbiota of Aedes albopictus before and after blood feeding on mice.
View Article and Find Full Text PDFBioorg Chem
September 2025
Aix Marseille Univ., CNRS UMR 7325 Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Campus de Luminy, 13288 Marseille cedex 09, France. Electronic address:
In the field of theranostics, triaminophenaziniums are promising molecules due to their intrinsic properties such as an absorbance beyond 500 nm associated with large molar extinction coefficients, high fluorescence quantum yields, as well as phototoxicity. This study explored how three triaminophenazinium salts relate in structure and activity, highlighting their potential as theranostic agents. The nature of the moiety in position 2 of the dyes was varied from H, to -CH or -Bu.
View Article and Find Full Text PDFRev Cardiovasc Med
August 2025
Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, 100730 Beijing, China.
Background: Intrinsic capacity (IC) is defined as the combination of all physical and mental (including psychosocial) capacities that an individual can rely on at any given time. Previous studies have shown that a decline in IC is linked to an increased mortality rate. Thus, this study aimed to evaluate the impact of IC on the 5-year mortality of older people with cardiovascular disease.
View Article and Find Full Text PDFUltrason Sonochem
September 2025
College of Science, Inner Mongolia University of Technology, Hohhot 010051, China.
In this study, the systematic investigation focused on how varying power levels of ultrasonic (US) pretreatment, when integrated with electrohydrodynamic (EHD) drying, influence the physicochemical properties of yam. Yam samples were subjected to ultrasonic pretreatment at 30 °C for 30 min using power levels of 0 W (Control), 150 W, 180 W, 210 W, 240 W, and 270 W, respectively, followed by drying in an EHD system. During the drying process, a range of metrics were measured, including moisture content, average drying rate, color change, as well as rehydration capacity.
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