Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rec.2022.05.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The degree of vascular calcification affects endovascular recanalization in chronic intracranial and extracranial large artery occlusion: A retrospective study.
Medicine (Baltimore)
September 2025
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Chronic cerebral artery occlusion is an important cause of cerebral ischemic events. Endovascular recanalization is an effective treatment for this condition, but its success depends on appropriate patient selection and assessment. This is a retrospective study that collected patients with chronic cerebral artery occlusion who underwent endovascular recanalization to determine how imaging features from computed tomography angiography - including the extent of internal carotid artery occlusion, the number of calcified vessels, and the degree of calcification in the occluded vessels - affect the success rate of recanalization.
View Article and Find Full Text PDFThe evolving landscape of targets for lipid lowering: from molecular mechanisms to translational implications.
Eur Heart J
September 2025
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Cardiovascular disease remains a major global health challenge, with dyslipidaemia being a key modifiable risk factor. While low density lipoprotein cholesterol (LDL-C) is the primary target for lipid-lowering therapies, recent evidence highlights the importance of triglycerides, apolipoprotein B (apoB), and lipoprotein(a) [Lp(a)] for residual cardiovascular risk. Current lipid-lowering therapies target key enzymes and proteins involved in cholesterol and lipid metabolism.
View Article and Find Full Text PDFAntidepressants stimulate lipoprotein(a) macropinocytosis via serotonin-enhanced cell surface binding.
J Lipid Res
August 2025
Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand; HeartOtago, University of Otago, Dunedin, New Zealand; Department of Molecular Medicine and EMBL Australia Node in Single Molecule Science, School of Biomedical Sciences, University of New South Wal
We recently found that plasminogen receptors regulate the plasma membrane binding and uptake of Lp(a) via macropinocytosis. In this study, we sought to further define lipoprotein(a) [Lp(a)] macropinocytosis, discovering an unexpected role for antidepressants and serotonin in the regulation of this process. We found that the tricyclic antidepressant imipramine enhanced Lp(a) uptake, in contradiction of its published role as a macropinocytosis inhibitor.
View Article and Find Full Text PDFDeveloping a novel diagnostic model for identifying high-risk plaques in new onset unstable angina pectoris using coronary CT angiography.
Front Endocrinol (Lausanne)
August 2025
The First Clinical College, The First Afiliated Hospital of Jinan University, Guangzhou, China.
Background: Limited evidence supports the use of electronic health records for developing prediction models to identify high-risk plaques in patients with unstable angina pectoris (UAP). This study aimed to develop and validate a practical high-risk plaque prediction model in patients with new onset UAP.
Methods: We prospectively enrolled consecutive patients presenting with new-onset UAP who underwent both coronary angiography and coronary computed tomography angiography (CCTA) at our center from January 2021 to December 2021.
PCSK9 gene Polymorphism and Assessment of Cardiovascular Risk and Prognosis in Patients With Hyperlipidemia: A Retrospective Cohort Study.
J Clin Hypertens (Greenwich)
August 2025
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) polymorphisms exhibit ethnic-specific associations with cardiovascular risk. However, their prognostic value for major adverse cardiovascular and cerebrovascular events (MACCE) in Asian populations remains undefined. This prospective cohort study enrolled 1969 patients (mean age 54.
View Article and Find Full Text PDF