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http://dx.doi.org/10.3389/fnagi.2022.908716 | DOI Listing |
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFJ Nutr
September 2025
Health and Kinesiology, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Department of Medicine, Division of Geriatrics and Gerontology, Emory University, Atlanta, GA, USA; Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL; Personalized Nutrition Initia
Background: Arterial stiffness, assessed via carotid femoral pulse wave velocity (cfPWV), is a marker of vascular aging that may contribute to cognitive decline. Serum carotenoids, with antioxidant properties, may mitigate these effects, but their role in moderating neurovascular-cognitive relationships remains unclear.
Objective: This study examined: (1) associations between cfPWV and executive function, (2) the contribution of serum carotenoids in predicting cfPWV, and (3) whether carotenoids moderate the relationship between cfPWV and executive function.
J Neurointerv Surg
September 2025
Geisinger Medical Center, Danville, Pennsylvania, USA.
Background: SURF was a prospective, multicenter, single-arm, observational study with core lab adjudication of radiographic data, assessing embolization of intracranial aneurysms (IAs) using WAVE Extra Soft Coils as part of SMART Coil System.
Methods: Adults undergoing IA embolization with the SMART Coil System (Penumbra, Inc.) comprising 75% of implanted coils and WAVE as the final finishing coil were enrolled at 43 global centers.
Am J Physiol Regul Integr Comp Physiol
September 2025
Human Neurovascular Control Laboratory, Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Transl Stroke Res
September 2025
Neurosurgical Service, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis Street, Boston, MA, 02115, USA.
The role of different imaging modalities-non-contrast CT (NCCT), CT perfusion (CTP), and diffusion-weighted imaging (DWI)-in selecting patients with large-core stroke for endovascular thrombectomy (EVT) is a subject of ongoing debate. This study aims to determine whether patients with large-core acute ischemic stroke (AIS) undergoing EVT triaged with CTP or DWI in addition to NCCT had different clinical outcomes compared to those only triaged with NCCT. We queried the Stroke Thrombectomy and Aneurysm Registry (STAR) for patients enrolled between 2014 and 2023 who presented with anterior-circulation AIS and large ischemic core (ASPECTS < 6) who underwent EVT in 41 stroke centers in the USA, Europe, Asia, and South America.
View Article and Find Full Text PDF