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A new series of low transition temperature mixures (LTTM) based on choline lactate quaternary ammonium salt and various hydrogen bond donors was prepared and characterized towards their physicochemical properties and usability as an enzymatic reaction mixture for lipase-catalyzed transesterification reactions. Studies of low transition temperature mixtures have shown a long-term stabilizing effect for lipase as well as a positive influence on lipase thermal stability. In the case of Ch[Lac]:Gly: EthGly increasing the stability of lipase by 8 °C (up to 55.2 °C) compared to the control sample. Conducted transesterification reactions were characterized by high yields - up to 98% - and high purity of the obtained products.
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http://dx.doi.org/10.1016/j.colsurfb.2022.112518 | DOI Listing |
FEMS Microbiol Ecol
September 2025
School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland, New Zealand, 1142.
The relationship between, and joint selection on, a host and its microbes-the holobiont-can impact evolutionary and ecological outcomes of the host and its microbial community. We develop an agent-based modelling framework for understanding the ecological dynamics of hosts and their microbiomes. Our model incorporates numerous microbial generations per host generation allowing selection on both host and microbes.
View Article and Find Full Text PDFJ Anim Sci
September 2025
Department of Animal Sciences, Laval University, Québec, QC G1V 0A6, Canada.
In pig production, weaning is a critical period where piglets face several environmental stressors. This transition leads to a significant growth reduction and can result in digestive disorders, including diarrhea. To formulate a feed that meets zinc (Zn) and copper (Cu) requirements during the weaning period while minimizing their release into the environment, it became evident that a more bioavailable micro-mineral supplement is necessary.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Quantum Dynamics Lab, Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar 140001, India.
The interstellar medium (ISM) is a complex and dynamic environment in which molecular collisions play a crucial role. Among these, protonated carbon chains are of great interest due to the presence of a permanent dipole moment and their relevance in describing astrochemical processes, making their detection possible in cold molecular clouds such as TMC-1. C5H+ (1Σg+) is an important molecule for understanding the formation and evolution of carbon-rich environments.
View Article and Find Full Text PDFMol Pharm
September 2025
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, U.K.
The presence of water significantly impacts the physical stability of amorphous solid dispersions (ASDs) by altering polymer molecular mobility. This study investigates the influence of low levels of absorbed water on the molecular dynamics and glass transition behavior of amorphous poly(vinylpyrrolidone--vinyl acetate) (PVP/VA). Melt-quenched PVP/VA discs were conditioned at controlled relative humidities (RH 8.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
China-New Zealand Joint Laboratory on Biomedicine and Health, State Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Resea
TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53 overexpression (MT-PHHs) is performed in xenografts.
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