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Background: One of the best methods for protection against respiratory diseases is the use of an N95 mask. Supply shortages have demonstrated a significant need for effective alternatives to N95 masks. Benefits of 3D-printed respirators over N95s include reduced cost and ease of production, widespread availability, reusability/sterilizability, and customizability. 3D-printed mask designs have been downloaded thousands of times; however, there is little to no data on the efficacy of these potential alternatives.
Methods: Three of the most popular 3D-printed respirator designs were modified to allow for the Occupational Safety and Health Administration (OSHA) quantitative fit testing that disperses saline into the ambient air and determines concentrations within the mask during multiple trials. Five volunteers conducted standardized fit tests of these masks, as well as an N95 and a KN95, and the results were compared.
Results: One of the 3D-printed respirators, low poly COVID-19 face mask respirator (mask 2), achieved a fit factor greater than 100 in every trial, representing sufficient fit according to OSHA protocols. The N95 mask achieved a sufficient fit in 60% of the trials, and none of the remaining masks provided a suitable fit factor reliably according to the OSHA fit test. Further trials showed no change in fit factor when different 3D-printable plastics are used or when a widely available high efficiency particulate air (HEPA) filter was used.
Conclusion: 3D-printed respirators provide a possible alternative to N95 masks to protect against respiratory pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Fit testing results demonstrate that certain 3D-printed mask designs may exceed the fit of N95 masks.
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http://dx.doi.org/10.1016/j.amjmed.2022.04.026 | DOI Listing |
Adv Eng Mater
July 2025
Department of Mechanical Engineering University of Nevada, Las Vegas, NV, US.
Highly contagious respiratory infection diseases such as COVID-19 can be transmitted by inhaling virus laden liquid droplets and short-range aerosols, released by an infected person. Particularly, in hospitals, spraying of the respiratory droplets containing pathogens from the conjunctiva or mucus of a susceptible person plays a key role in transferring the infectious diseases. N95 filtering respirators are a critical personal protective equipment.
View Article and Find Full Text PDFJ Occup Environ Hyg
September 2025
Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, US Food and Drug Administration (FDA), Oak Ridge, Tennessee.
This work assesses the current characterization framework of single-use personal protective equipment (PPE) per recognized consensus standards and presents a novel quantitative approach to refining characterization of barrier materials and predicting PPE performance. Scanning electron microscopy (SEM) and image analysis software (Diameter J) were used to examine the microscopic fiber and pore structure of filter layers of surgical N95 filtering facepiece respirators, before and after exposure to chemicals used in decontamination modalities (vaporized hydrogen peroxide or ozone). The effect of porosity on penetration was assessed by bacterial filtration efficiency (BFE) testing.
View Article and Find Full Text PDFBiosaf Health
August 2025
Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, MS320, Reno 89557 Nevada, United States of America.
The role of personal protective equipment (PPE) in protecting against exposure to infectious agents and toxic chemicals is well-established. However, the global surge in PPE demand during the pandemic exposed challenges, including shortages and environmental impacts from disposable waste. Developing effective, scalable, and sustainable decontamination methods for the reuse of PPE is essential.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Research and Medical Innovation, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, 10300, Thailand.
Long-term exposure to particulate matter (PM2.5) primarily affects the respiratory and cardiovascular systems, resulting in millions of premature deaths per year. However, the influence of PM2.
View Article and Find Full Text PDFCureus
July 2025
Department of Otolaryngology - Head and Neck Surgery, Singapore General Hospital, Singapore, SGP.
Background The use of N95 masks is ubiquitous in the healthcare setting to protect against respiratory tract infections and even more so since the emergence of the SARS-CoV-2 virus (COVID-19) infection. The purpose of this study was to assess the effect of N95 masks on nasal symptoms. Methods We designed a questionnaire to survey nasal symptoms such as rhinorrhoea, obstruction, sneezing, and itching that may be experienced whilst wearing the different models of N95 masks.
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