The emerging role of biomaterial applications in cerebral lymphatic surgical interventions: A narrative review.

The cerebral lymphatic system plays a critical role in central nervous system (CNS) homeostasis through fluid regulation, toxin clearance, and immune modulation. Recent discoveries in the glial-lymphatic (glymphatic) and meningeal lymphatic systems have demonstrated their involvement in a spectrum of CNS pathologies such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS), traumatic brain injury (TBI), stroke, and cancers. This review summarizes current understanding of the cerebral lymphatic system's mechanisms and their contribution to CNS health.

The Impact of E-Learning Platforms on Dementia Knowledge Acquisition Among General Public: A Systematic Review.

Unlabelled: Digital learning environments, including Massive Open Online Courses (MOOCs), synchronous web-based seminars, and interactive educational modules, have demonstrated significant efficacy as pedagogical instruments in dementia education, circumventing traditional instructional constraints. This review explores the impact of e-learning platforms on dementia knowledge acquisition among the general public, including informal caregivers.

Methods: A systematic review was conducted using four databases: PubMed, SCOPUS, Web of Science, and Science Direct.

The Clinical Pearls and Pitfalls of Using the Symani System in Microsurgery.

The improved stability and controllability of robotics has the potential to expand the spectrum of reconstructive surgery. Until recently, however, no robot was designed specifically for microsurgery. The present study aims to summarize the clinical pearls and pitfalls of utilizing the Symani Surgical System in microsurgical practice.

Isolation, Characterization and Optimization of Lead Resistant Bacteria and Possible Application in Bioremediation.

The present study describes three lead-resistant bacterial isolates (KPb1, KPb5, and KPb7) that were isolated from water samples of the River Holy Kali Bein, Punjab, India. The isolates were found to resist and bioaccumulate lead, and maximum tolerated concentrations were found to be 750 mg/L by KPb1 and KPb5, and 800 mg/L by isolate KPb7, respectively. Additionally, isolates KPb1, KPb5, and KPb7 had Multiple Antibiotic Resistance (MAR) index values of 0.

Comparative Outcomes of Proton versus Photon Post-Mastectomy Radiation Therapy in Pre-Pectoral Implant-Based Breast Reconstruction.

Introduction: The rising popularity of pre-pectoral implant-based breast reconstruction (PP-IBBR) and proton radiation lacks outcomes data. We aim to compare complications in PP-IBBR with photon (XRT) versus proton (PRT) post-mastectomy radiotherapy (PMRT).

Methods: A single-institution retrospective cohort study included breast cancer patients undergoing mastectomy and PP-IBBR with PMRT (January 2020-October 2022) with two-year follow-up after surgery.

Health inequity: Possibilities of initiating pulmonary telerehabilitation programs for adults with chronic obstructive pulmonary disorders in conflict and low-resourced areas; A mixed-method phenomenological study.

Objective: The "triple problems of COPD"-underdiagnosis, underrecognition, and underdevelopment of pulmonary rehabilitation programs-are global. Pulmonary telerehabilitation (PTR) may solve these problems. This study aims to explore the possibility of launching PTR programs for adults in an area of conflict and low resources.

Linear and Area Coverage With Closed Incision Negative Pressure Therapy Management: International Multidisciplinary Consensus Recommendations.

Closed incision negative pressure therapy (ciNPT) with foam dressings has received broad recognition for its ability to support incision healing for a variety of surgical procedures. Over time, these dressings have evolved to include linear and 'area' shapes to better conform to different incision types and surface geometries. To address new studies on these configurations and provide guidance for dressing selection, an international, multidisciplinary panel of experts was convened.

The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailty in Malaysia: The AGELESS Trial.

Background: Cognitive frailty (CF) in older adults is a potentially reversible syndrome that may benefit from lifestyle-based multidomain interventions. This study assessed the AGELESS intervention's impact on cognitive, physical, vascular, dietary, and psychosocial outcomes, along with its cost-effectiveness, in a Low-Middle-Income Country (LMIC).

Methods: The AGELESS randomized controlled trial recruited 106 older adults (above 60 years) from Klang Valley, Malaysia, with (pre)-CF (≥ 1 Fried's criteria and Clinical Dementia Rating scale = 0.

Unveiling the key elements of effective preventive strategies: Insights into addressing work-related musculoskeletal disorders among physiotherapists.

BackgroundPhysiotherapists play a critical role in managing musculoskeletal health, yet they remain highly vulnerable to work-related musculoskeletal disorders (WMSDs) due to the physical demands of their profession.ObjectiveThis study explores the awareness of strategies used in preventing WMSDs and their effectiveness, motivation, and barriers to preventing WMSDs among physiotherapists.MethodsThis qualitative study was administered among physiotherapists in Malaysia, where semi-structured interviews with a modified interview guide were used through an online platform.

Biopsychosocial Determinants for Total Knee Replacement Decisions Among Older Adults With Chronic Knee Osteoarthritis: A Scoping Review.

Total knee replacement (TKR) is a common surgical intervention for older adults with chronic knee osteoarthritis (KOA). Given the prevalence of comorbidities in this population, health priorities may vary, influencing decision-making regarding TKR. Despite the increasing number of TKRs, no scoping review has systematically examined the determinants shaping older adults' decisions using a biopsychosocial (BPS) model.

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes.

This study explores hyperglycemia's influence on knee osteoarthritis (KOA) related symptoms, physical performance, physical activity level, radiographic severity, and inflammation in older adults. Prolonged hyperglycemic states contribute to advanced glycation end-product (AGE) formation, which worsens KOA symptoms. Capillary blood glucose (CBG) and glycated hemoglobin A1C (HbA1C) levels are commonly used in laboratory tests for glycemic assessment, offering distinct advantages and limitations.

The Role of Lead Shielding in Preventing Gamma Radiation-Induced Microleakage in Nanohybrid Composite Restorations: An In Vitro Study.

Introduction: Marginal microleakage is a significant factor that contributes to the failure of cavity restorations, ultimately leading to recurrent caries. These failures are primarily attributed to the properties of the restorative materials, which are often influenced by various environmental factors. Gamma radiation has been shown to have deleterious effects not only on dental hard tissues but also on composite restorative materials, potentially increasing microleakage.

Microsurgery Education among U.S. Plastic Surgery Residency Programs.

Microsurgery is a core component of U.S. plastic surgery residency curriculum.

User-centred design of ChestCare: mHealth app for pulmonary rehabilitation for patients with COPD; a mixed-methods sequential approach.

Background: The increasing prevalence and burden of chronic obstructive pulmonary disorder (COPD), the challenges in implementing pulmonary rehabilitation (PR) programs and the limited availability of alternatives and supportive programs to serve patients with COPD necessitate the development of pulmonary telerehabilitation (PTR) systems to provide patients with COPD with PR programs.

Objective: This study aimed to design and develop the ChestCare mobile Health app using user-centred design (UCD) approach. Thus, it provided PTR for patients with COPD, enhancing their self-management of symptoms and improving their compliance with PR programs.

Motivation, barriers and preferences of lifestyle changes among older adults with frailty and mild cognitive impairments: A scoping review of qualitative analysis.

Lifestyle intervention has proven effective in managing older adults' frailty and mild cognitive impairment issues. What remains unclear is how best to encourage lifestyle changes among older adults with frailty and Mild Cognitive Impairment (MCI). We conducted searches in electronic literature searches such as PubMed, Scopus, Cochrane Reviews, ProQuest, and grey resources to find articles published in English between January 2010 and October 2023.

The Efficacy of Single-Application NPWTi-d for the Salvage of Infected Breast Prostheses: A Multi-Center Study.

Background: Breast prosthesis infections are challenging and traditionally managed with prosthesis removal and delayed reconstruction. Single-application negative pressure wound therapy with instillation and dwell (NPWTi-d) has shown promise for salvaging infected implants, though prior studies have been small and heterogeneous. This study analyzes outcomes and compares protocols from four institutions.

Presentation and Management of Silicone Lymphadenopathy: A Single Institutional Retrospective Cohort Study.

Introduction: Silicone Lymphadenopathy (SL) is a complication of breast implants that involves migration of silicone to nearby soft tissue/lymph nodes. Data on its clinical features and management is scarce. We aimed to identify the clinical presentation and management of SL.

A qualitative study on the impact and participation in the AGELESS multidomain intervention: Insights from older adults with cognitive frailty and their caregivers.

Background: Cognitive frailty (CF) is a major precursor to dementia, and multidomain interventions have the potential to delay, prevent or reverse its early onset. However, the successful translation and sustainability of such interventions in real-life settings remain uncertain. In this study, we aimed to explore the insights of older adults with CF and their caregivers regarding the impact and participation in the AGELESS multidomain intervention.

The WE-RISE™ multi-domain intervention: a feasibility study for the potential reversal of cognitive frailty in Malaysian older persons of lower socioeconomic status.

Background: Cognitive frailty (CF) is an emerging concern among older persons, particularly within lower socioeconomic statuses (SES) populations. Currently, there is limited evidence on the potential reversibility of CF through multi-domain interventions within this demographic. This study aimed to investigate the effectiveness of the WE-RISE™ multi-domain intervention in addressing the potential reversibility of CF among community-dwelling older persons of lower SES, the intervention effects on multiple health dimensions, and to determine if WE-RISE™ is of low cost.

Revision Surgeries After Proton vs Photon Postmastectomy Radiation Therapy in Prepectoral Implant-Based Breast Reconstruction.

Background: Postmastectomy radiation therapy (PMRT) improves disease-free survival in breast cancer but reduces aesthetic satisfaction. Proton PMRT has gained popularity because it results in fewer systemic complications. There is a lack of data regarding revision surgeries for prepectoral implant-based breast reconstruction (PP-IBBR) following radiation.

Limited health literacy increases the likelihood of cognitive frailty among older adults.

Background: Cognitive frailty is a dual geriatric syndrome that is preventable with lifestyle changes. Lifestyle changes are influenced by literacy level. However, the association between limited health literacy (HL) and cognitive frailty (CF) is yet to be discovered.

Perceptions of using exoskeleton technology among physiotherapists and stroke survivors in Malaysia: a mixed methods study.

Exoskeleton technology has the potential to enhance the functional abilities of individuals with upper or lower limb dysfunction, including stroke survivors. However, its adoption in Malaysia has been limited due to its restricted availability in rehabilitation centres and hospitals. In this study, we aim to explore the perceptions and opinions of physiotherapists and stroke survivors regarding exoskeleton technology, focusing on identifying desired design features and investigating their views on its use in rehabilitation.

Transcranial alternating current stimulation for older adults with cognitive impairment: A bibliometric and knowledge map analysis.

As the population ages, cognitive impairment leading to dementia and related disorders presents an increasingly significant societal burden. Transcranial alternating current stimulation emerges as a potential noninvasive treatment, yet remains an area of ongoing research. Using the Science Citation Index Expanded within the Web of Science Core Collection database, we identified 144 relevant articles spanning from 1965 to December 1st, 2023.

Transition of Physical, Psychological, and Cognitive Frailty and Its' Associated Determinants in Malaysian Older Adults: A 5-Year Follow-up Study.

Frailty, a multifaceted syndrome, affects approximately 26% of older adults globally, yet there are limited data on the prevalence and longitudinal impact of frailty subtypes. Therefore, in this study, we aim to determine the prevalence of physical, psychological, and cognitive frailty, transitions between subtypes, and associated health determinants among Malaysian community-dwelling older adults. This study is part of the longitudinal aging study in Malaysia (LRGS Ageless and TUA).

Meta-Analysis Comparing Outcomes of Two Different Closed Incision Negative Pressure Systems in Breast Surgery and Implications to Cost of Care.

Background: Surgical site complication (SSC) rates in breast surgery have been reported between 2.25% and 53%. Use of incision management may help reduce the risk of SSCs.