Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies (ART). So far, the clinical evaluation of embryo quality depends on embryo morphology. However, the clinical pregnancy rate is still low. Therefore, new indicators are needed to further improve the evaluation of embryo quality. Several studies have shown that the decrease of sperm-specific protein actin-like 7A (ACTL7A) leaded to low fertilization rate, poor embryo development, and even infertility. The aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo quality. In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization (IVF) laboratory outcomes. Our results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo quality. Furthermore, the protein levels showed a significant correlation with fertilization outcomes of ART. ACTL7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo arrest. In conclusion, sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226699 | PMC |
| http://dx.doi.org/10.4103/aja2021111 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of prolonged unsaturated fatty acid supplementation on reproductive competence and metabolic profiles in serum and follicular fluid of Holstein heifers.
Anim Reprod Sci
September 2025
Department of Animal Production and Animal Nutrition, University of Sao Paulo, Pirassununga 13635-900, Brazil. Electronic address:
This study evaluated the effects of a 120-d dietary supplementation with unsaturated fatty acids from soybean grain and flaxseed on oocyte quality, in vitro embryo quality and production, and the metabolic profiles of blood and follicular fluid in Holstein heifers. Twenty-four heifers were assigned to the following treatments: a control diet (CON) and diets supplemented with whole raw soybeans (WRS) or flaxseed (FLX), both formulated to increase ether extract content to approximately 4.5 % dry matter (DM).
View Article and Find Full Text PDFAssociations of urinary metabolite concentrations of phthalates and their alternatives with reproductive outcomes among women receiving in vitro fertilization: A repeated measurement analysis.
Environ Int
September 2025
Center for Public Health Laboratory Service, Institute of Environmental Health, Wuhan Centers for Disease Prevention & Control, Wuhan, Hubei 430024, PR China. Electronic address:
Background: Studies suggest that phthalates (PAEs) may disrupt female reproductive health, but few have explored repeated measurements of PAE and their alternative exposure and their joint impact on reproductive outcomes.
Objectives: To evaluate the associations of repeatedly measured urinary levels of PAE and their alternative metabolites with reproductive outcomes in women receiving in vitro fertilization (IVF).
Methods: This study included 704 women undergoing IVF between February and October 2023 in Chongqing, China.
Bio-Scaffold Developed With Decellularized Human Amniotic Membrane Composite 3D Umbilical Cord Mesenchymal Stem Cell Spheroids Accelerate the Repair of Rat Defective Wounds.
FASEB J
September 2025
Department of Plastic Surgery and Burn, Third XiangYa Hospital, Central South University, Changsha, Hunan, China.
Defective wounds pose health risks, and treatment is challenging. Umbilical cord-derived mesenchymal stem cells (UCMSCs) show promise for healing. Primary UCMSCs were isolated and extracted in vitro, and the proliferation and differentiation characteristics were detected by flow cytometry and trilineage differentiation, and a 3D spherical cell culture was performed.
View Article and Find Full Text PDFOxidative stress index of porcine follicular fluid influences meiotic maturation and embryo development during culture.
Vet World
July 2025
Bio-Innovation Research Center, Tokushima University, 779-3233 Tokushima, Japan.
Background And Aim: Porcine follicular fluid (pFF) is frequently used to mimic the follicular microenvironment during maturation (IVM) of oocytes. However, the influence of oxidative stress levels within pFF on oocyte quality and embryo development remains unclear. This study aimed to investigate how varying oxidative stress index (OSI) of pFF affect porcine oocyte meiotic progression, fertilization, and embryonic development during IVM.
View Article and Find Full Text PDFContrasting contribution of resident and repopulated brain macrophages in sustaining sleep-wake circuitry.
Commun Biol
September 2025
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sleep is a complex behavior regulated by various brain cell types. However, the roles of brain-resident macrophages, including microglia and CNS-associated macrophages (CAMs), particularly those derived postnatally, in sleep regulation remain poorly understood. Here, we investigated the effects of resident (embryo-derived) and repopulated (postnatally derived) brain-resident macrophages on the regulation of vigilance states in mice.
View Article and Find Full Text PDF