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Background: Posterior fossa AVMs constitute about 10% of AVMs and are associated with a higher rate of hemorrhage and increased morbidity and mortality rates necessitating treatment with rare exception. Cerebellar AVMs differ markedly from their supratentorial counterparts in that there are no perforating vessels involvement, drainage into the deep cerebral venous system, or presence of eloquent functional area except for the dentate nucleus. While Yaşargil has classified cerebellar AVMs into seven subtypes according to their location, de Oliveira . have classified them using a more impactful grading system based on the size, location, and involvement of the dentate nucleus with the highest risk being III (size over 4 cm) C (mixed superficial and deep location) * (dentate involvement). In this extensive AVM with multiple arterial feeders from the SCA, AICA, and PICAs, preoperative embolization facilitates the safe surgical removal.
Case Description: We present the case of resection of de Oliveira . IIIC* cerebellar AVM highlighting the tenets of preoperative embolization, wide surgical exposure with an extended retrosigmoid approach, arachnoidal dissection of the SAC, AICA, and PICA feeders, parenchymal dissection with preservation of the dentate nucleus, and preservation of venous drainage until complete disconnection. The patient consented to surgery after presenting with hemorrhage and developed hydrocephalus and CSF leak, managed successfully.
Conclusion: de Oliveira . classification is highly impactful in grading posterior fossa AVMs.
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http://dx.doi.org/10.25259/SNI_217_2022 | DOI Listing |
Cell Rep
September 2025
Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:
An adverse gestational environment is a risk factor for the development of psychiatric disorders. Although studies have implicated modifications in neuronal DNA and chromatin, how these changes come about and lead to abnormal behaviors is not known. We sought to identify persistent DNA/chromatin and transcriptomic signatures induced by a proinflammatory gestational environment in the ventral dentate gyrus (vDG), a hippocampal region linked to anxiety.
View Article and Find Full Text PDFMov Disord
September 2025
Movement Investigation and Therapeutics Team, Sorbonne Université, INSERM U1127, CNRS UMR 7225, Paris Brain Institute, Paris, France.
Background: Cervical dystonia is characterized by abnormal neck and head movements, possibly related to a dysfunction of the interstitial nucleus of Cajal (INC) and the head neural integrator, a system responsible for the control of head and eye movements. However, neuroanatomical evidence of alterations in the head neural integrator in cervical dystonia is sparse.
Objectives: We investigated structural and functional integrity of the INC and its connections in cervical dystonia.
Neuropharmacology
August 2025
Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA. Electronic address:
Background: Post traumatic stress disorder (PTSD) is debilitating and more prevalent in women than men. While this suggests there are sex differences in the way neural systems respond to traumatic stress, identifying these systems are challenging. As such, studies designed to identify neural systems that are differentially sensitive to traumatic stress are needed.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Pharmacology, Nippon Medical School, Tokyo, 113-8602, Japan.
Modulation of synaptic transmission in the deep cerebellar nuclei, a major output region of the cerebellum, is essential for regulating motor and non-motor functions by controlling information flow from the cerebellar cortex. In this study, we aimed to investigate the effects of dopamine (DA) and noradrenaline (NA) on glutamatergic synaptic transmission using cerebellar slices from both male and female Wistar rats. Stimulation-evoked excitatory postsynaptic currents (eEPSCs) were recorded from deep cerebellar nuclei neurons using whole-cell patch-clamp technique.
View Article and Find Full Text PDFTransl Psychiatry
August 2025
Fudan-SANS Neuroscience Center, Fudan University, Shanghai, China.
Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity, with growing evidence suggesting hypoalertness as a contributing factor to its associated cognitive impairments. Despite promising results from behavioral interventions employing external stimuli to improve cognitive function, the underlying neural mechanisms remain inadequately understood. Here, we identify the supramammillary nucleus (SuM) as a critical neural substrate involved in modulating alertness and cognitive deficits associated with ADHD.
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