Publications by authors named "Clement Tarrano"
Background: Cervical dystonia is characterized by abnormal neck and head movements, possibly related to a dysfunction of the interstitial nucleus of Cajal (INC) and the head neural integrator, a system responsible for the control of head and eye movements. However, neuroanatomical evidence of alterations in the head neural integrator in cervical dystonia is sparse.
Objectives: We investigated structural and functional integrity of the INC and its connections in cervical dystonia.
Developmental variability in paediatric SGCE-related myoclonus dystonia syndrome.
Dev Med Child Neurol
June 2025
740–749
View Article and Find Full Text PDFPsychiatric symptoms are common in neurodevelopmental movement disorders, including some types of dystonia. However, research has mainly focused on motor manifestations and underlying circuits. Myoclonus-dystonia is a rare and homogeneous neurodevelopmental condition serving as an illustrative paradigm of childhood-onset dystonias, associated with psychiatric symptoms.
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- The study explores myoclonus dystonia caused by a variant in the SGCE gene, focusing on the microarchitectural brain abnormalities linked to this rare condition.
- Researchers compared the brain structures of 18 MYC/DYT-SGCE patients with 24 healthy volunteers using advanced imaging techniques to assess neurite organization.
- Results indicate that patients exhibited changes in cerebellar structure, with specific alterations correlating to the severity of dystonia, while no links were found between myoclonus severity and the microarchitectural measurements.
Article Synopsis
- This study investigates the non-motor aspects of myoclonus dystonia, focusing on the sense of agency, which is how individuals perceive control over their actions, and how disruptions in this sense can affect movement disorders.* -
- The research compared 19 patients with myoclonus dystonia (stemming from a specific genetic variant) to 24 healthy participants, revealing that the patients had a significant impairment in their explicit sense of agency, while their implicit sense remained unaffected.* -
- Neuroimaging analyses showed structural and functional abnormalities in the cerebellum and its connectivity with the pre-supplementary motor area, suggesting these brain regions play a crucial role in the altered sense of agency in patients with my
Non-Motor Symptoms and Quality of Life in Patients with PRRT2-Related Paroxysmal Kinesigenic Dyskinesia.
Mov Disord Clin Pract
July 2023
Background: Monoallelic pathogenic variants of often result in paroxysmal kinesigenic dyskinesia (PKD). Little is known about health-related quality of life (HrQoL), non-motor manifestations, self-esteem, and stigma in patients with PKD.
Objectives: We investigated non-motor symptoms and how they related to HrQoL in a genetically homogeneous group of -PKD patients.
Background: Cervical dystonia (CD) is a form of isolated focal dystonia typically associated to abnormal head, neck, and shoulder movements and postures. The complexity of the clinical presentation limits the investigation of its pathophysiological mechanisms, and the neural networks associated to specific motor manifestations are still the object of debate.
Objectives: We investigated the morphometric properties of white matter fibers in CD and explored the networks associated with motor symptoms, while regressing out nonmotor scores.
How does Tourette syndrome impact adolescents' daily living? A text mining study.
Eur Child Adolesc Psychiatry
December 2023
Article Synopsis
- Tourette syndrome primarily affects children and adolescents, yet its impact on their daily lives has not been thoroughly researched.
- A study involving 62 adolescents analyzed their experiences at school, home, and socially, focusing on which aspects of Tourette syndrome presented the most challenges and their future outlook.
- Key findings indicated that tic severity worsened school challenges, comorbidities impacted social interactions, and younger patients expressed more negative feelings about their futures, with social stigma being a recurring theme.
Somatotopy of cervical dystonia in motor-cerebellar networks: Evidence from resting state fMRI.
Parkinsonism Relat Disord
January 2022
Introduction: Cervical dystonia is the most frequent form of isolated focal dystonia. It is often associated with a dysfunction in brain networks, mostly affecting the basal ganglia, the cerebellum, and the somatosensory cortex. However, it is unclear if such a dysfunction is somato-specific to the brain areas containing the representation of the affected body part, and may thereby account for the focal expression of cervical dystonia.
View Article and Find Full Text PDFLong-term effect of apomorphine infusion in advanced Parkinson's disease: a real-life study.
NPJ Parkinsons Dis
June 2021
Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known. Data from consecutive advanced Parkinson's disease patients treated in routine care were retrospectively collected over 24 months after CSAI initiation, with a focus on the 39-item Parkinson's disease questionnaire (PDQ-39). We determined predictors of CSAI discontinuation and HRQoL improvement using multiple regression analysis.
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- * The study discusses two new cases alongside five previously reported cases where patients demonstrated similar neurological issues, and most responded well to treatment with immunoglobulins or steroids.
- * Recognizing these neurological manifestations early is crucial, as prompt treatment can lead to significant recovery in affected patients.
Article Synopsis
- Myoclonus-dystonia (MD) is a neurological syndrome involving muscle jerks and dystonia, often linked to mental health issues, caused by dysfunction in specific brain pathways.
- A study using the Stop Signal Task examined the reactive and proactive inhibitory control in MD patients, comparing those with and without deep brain stimulation treatment to healthy controls.
- Findings revealed that unoperated MD patients had impaired proactive inhibition, while those with deep brain stimulation had issues with reactive inhibition, indicating different effects on inhibitory control depending on the treatment status.
Background: Abnormal sensory processing, including temporal discrimination threshold, has been described in various dystonic syndromes.
Objective: To investigate visual sensory processing in DYT-SGCE and identify its structural correlates.
Methods: DYT-SGCE patients without DBS (DYT-SGCE-non-DBS) and with DBS (DYT-SGCE-DBS) were compared to healthy volunteers in three tasks: a temporal discrimination threshold, a movement orientation discrimination, and movement speed discrimination.