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A large and increasing number of scientific domains pushes for high neutron imaging resolution achieved in reasonable times. Here we present the principle, design and performance of a detector based on infinity corrected optics combined with a crystalline GdGaO : Eu scintillator, which provides an isotropic sub-4 µm true resolution. The exposure times are only of a few minutes per image. This is made possible also by the uniquely intense cold neutron flux available at the imaging beamline NeXT-Grenoble. These comparatively rapid acquisitions are compatible with multiple high quality tomographic acquisitions, opening new venues for in-operando testing, as briefly exemplified here.
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http://dx.doi.org/10.1364/OE.448932 | DOI Listing |
Chem Rev
September 2025
Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
Achieving precise control of materials synthesis is a cornerstone of modern manufacturing, driving efficiency, functionality, and device innovation. This review examines the roles of transmission electron microscopy (TEM) and neutron scattering (NS) in advancing our understanding of these processes. TEM offers atomic-scale insights into nucleation, growth, and phase transitions, while NS provides an analysis of reaction pathways, phase evolution, and structural transformations over broader length scales.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Glioblastoma is a highly malignant brain tumor with few available therapeutic options, for which boron neutron capture therapy (BNCT) has emerged as a promising precision radiotherapy approach. However, its efficacy remains suboptimal due to inadequate tumor targeting of boron agents and lack of in vivo visualization. Herein, a gadolinium-boron integrated lipid nanocarrier (BPA-F&DOTA-Gd@LIPO-ANG) was developed for targeted boron delivery and MRI-guided BNCT.
View Article and Find Full Text PDFMol Ther Oncol
September 2025
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan.
Boron neutron capture therapy (BNCT) shows potential for the treatment of glioblastoma, the most aggressive form of primary brain tumor. Recently, ferroptosis, a cell death triggered by phospholipid peroxidation, has been identified as an important process in tumor therapy. However, the ferroptosis in BNCT has not been fully explored.
View Article and Find Full Text PDFRev Sci Instrum
September 2025
J-PARC Center, Japan Atomic Energy Agency, 2-4 Shirakata, Tokai, Naka, Ibaraki 319-1195, Japan.
A cryogenic tensile testing system for in situ neutron diffraction measurement, incorporating macroscopic strain distribution measurement through the Digital Image Correlation (DIC) method, was developed. By integrating this system with a versatile horizontal load frame, tensile tests can be conducted within the temperature range from room temperature to 20 K. A tentative measurement combining in situ neutron diffraction and the DIC technique was performed on an ultrafine-grained 304 stainless steel during tensile deformation at 77 K.
View Article and Find Full Text PDFPlant Physiol
September 2025
Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831.
Microtubule-associated proteins (MAPs) play important roles in cellulose biosynthesis in plants. However, the molecular mechanisms mediating their interactions with cortical microtubule arrays remain to be elucidated. Here, we investigated companion of cellulose synthase 1 (CC1), an Arabidopsis (Arabidopsis thaliana) MAP that stabilizes cellulose biosynthesis during salt stress by maintaining the integrity of the cortical microtubule array.
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