Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This systematic review was conducted to investigate the effects of vitamin E and omega-3 used alone and in combination on the frequency and intensity of hot flushes (primary outcomes) and adverse effects (secondary outcome) in menopausal women. English and Persian databases were searched until March 18, 2021. The quality of the published papers was evaluated using Cochrane Handbook and the meta-analysis was conducted in RevMan 5.3. Heterogeneity was assessed using I. In cases with substantial heterogeneity, a random effects model was used instead of a fixed effects model. A total of 387 papers were obtained from the databases. Finally, 10 papers with a sample size of 1100 participants entered the systematic review and a meta-analysis was conducted on nine of them. The results of the meta-analysis of two studies indicated that using vitamin E and omega-3 in combination significantly reduced the intensity of hot flushes compared to the placebo (mean difference (MD): -0.35; 95% CI: -0.48 to -0.21). The mean frequency (MD: -0.50; 95% CI: -1.58 to 0.58) and intensity (SMD: -0.61; 95% CI: -1.50 to 0.29) of hot flushes in the omega-3 group and the frequency of hot flushes (SMD: -0.21; 95% CI: -0.47 to 0.04) in the vitamin E group showed no significant differences with the placebo. No serious adverse effects were reported in the studies. Given the low number of RCTs, more clinical trials with larger sample size are required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/20533691221083196 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Views of Menopause and Hormone Therapy Associations with Hormone Therapy Use in US Women Aged 50-79.
Womens Health Rep (New Rochelle)
September 2025
The Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Objective: To explore symptoms, knowledge levels, perceptions, and use related to menopause and hormone therapy (HT) and to examine the factors associated with HT use and HT perceptions in perimenopausal and postmenopausal women.
Materials And Methods: We used a sample of 98 perimenopausal and postmenopausal women who aged 50-79 and participated in the Sex, ApoE-4, γ-aminobutyric acid, and Episodic memory (SAGE) study ( = 64.24, = 7.
Increased and sustained physical activity in postmenopausal women: 2-year follow-up of a resistance training intervention.
Maturitas
August 2025
Unit of Physiotherapy, Division of Prevention, Rehabilitation and Community Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden. Electronic address:
Objectives: To assess whether levels of physical activity can be modified and sustained for 2 years in postmenopausal women with initially low physical activity levels participating in a randomised controlled trial.
Study Design: Postmenopausal women with vasomotor symptoms and low activity levels were randomised to a 15-week supervised full-body resistance training program three times/week or a control group maintaining low activity. After the intervention, controls were offered an introductory resistance training session and 15-week gym membership.
FDA approves Veozah (Fezolinetant) for menopausal symptoms: a new nonhormonal option.
Ann Med Surg (Lond)
September 2025
Department of Medicine, Georgia State University, Atlanta, USA.
Menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats, significantly impact the quality of life for many women. While hormone therapy remains a standard treatment, it is not suitable for all patients due to contraindications, safety concerns, or personal preferences. Fezolinetant (Veozah), a non-hormonal neurokinin-3 receptor (NK3R) antagonist, has emerged as a novel alternative for managing moderate to severe menopausal VMS.
View Article and Find Full Text PDFVasomotor Symptoms of Menopause, Sympathetic Activity, and Blood Pressure in Postmenopausal Females.
Am J Physiol Heart Circ Physiol
September 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota.
Objectives: While evidence suggests an association between vasomotor symptoms (VMS; hot flushes and night sweats) and elevated blood pressure (BP), it remains unknown whether females who experience VMS have elevated muscle sympathetic nerve activity (MSNA), a major modulator of BP. We hypothesized that postmenopausal females with VMS would have elevated BP and MSNA at rest and during stress compared to age-matched females without VMS.
Methods: Participants were grouped based on whether they currently or previously experienced VMS (n=43) or never experienced VMS (non-VMS; n=26).
Gonadotropin trajectories among postmenopausal women not using hormone therapy.
Menopause
September 2025
Department of Epidemiology and Environmental Health, State University of New York at Buffalo, Buffalo, NY.
Objective: While evidence suggests that gonadotropins may play an important role in aging-related changes in body composition and health outcomes, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) patterns have not been well characterized in older women. We characterized patterns of FSH and LH change over time after menopause.
Methods: In a sample of 291 postmenopausal women from the Women's Health Initiative OsteoPerio study who were not using hormone therapy, we estimated FSH and LH trajectories over a 20-year period using group-based trajectory modeling.