Exosome-Mediated Angiogenesis Underlies LVAD-Induced Bleeding in Patients With End-Stage Heart Failure.

JACC Basic Transl Sci

Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York, USA.

Published: March 2022


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993900PMC
http://dx.doi.org/10.1016/j.jacbts.2022.01.011DOI Listing

Publication Analysis

Top Keywords

exosome-mediated angiogenesis
4
angiogenesis underlies
4
underlies lvad-induced
4
lvad-induced bleeding
4
bleeding patients
4
patients end-stage
4
end-stage heart failure
4
exosome-mediated
1
underlies
1
lvad-induced
1

Similar Publications

The role of miR-10b-5p in prostate cancer and its exosome-mediated angiogenesis effect.

Cancer Genet

August 2025

The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, China; Department of Urology, Gansu Provincial Hospital, Lanzhou 730000, China. Electronic address:

Objective: Prostate cancer (PCa) continues to be a major cause of cancer-related mortality globally, underscoring the critical need for novel therapeutic strategies. This study investigates the oncogenic function of miR-10b-5p in PCa progression and evaluates its potential as both a diagnostic marker and therapeutic target.

Methods: miR-10b-5p was initially identified as a candidate oncogene through bioinformatic analysis of The Cancer Genome Atlas (TCGA) PCa data, followed by validation of its expression levels in clinical PCa specimens via fluorescence in situ hybridization (FISH).

View Article and Find Full Text PDF

Exosomal SPRY4 from adipogenic BMSCs impairs angiogenesis via the PTPRB/TIE2/PI3K axis in Steroid-induced osteonecrosis of the femoral head.

Stem Cell Res Ther

July 2025

Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Steroid-induced osteonecrosis of the femoral head (SONFH) drives irreversible bone collapse, yet current therapies inadequately target the disrupted angiogenic-osteogenic coupling central to its pathogenesis. Although pathological adipocyte hyperplasia is a hallmark of SONFH, the mechanisms by which adipogenic bone marrow mesenchymal stem cells (BMSCs) suppress angiogenesis remain unresolved. Emerging evidence implicates exosomes as mediators of adipose-vascular crosstalk, yet their role in SONFH-associated vasculopathy remains unexplored.

View Article and Find Full Text PDF

Insulin growth factor 2 contributes to adipose stem cell-derived exosome mediated angiogenesis against hind-limb ischemia injury.

Cytokine

September 2025

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; Tianjin General Surgery Institute, Tianjin, China; Tianjin Key Laboratory of Precise Vascular Reconstruction and Organ Function Repair, China. Electronic address:

Critical limb ischemia is a severe stage when hypoperfusion occurs in patients with lower extremity arteriosclerotic obliterans. Exosomes have emerged as a key therapeutic agent for lower extremity ischemia. However, how these exosomes take effects on ischemic limb is still unknown.

View Article and Find Full Text PDF

Mesenchymal stem cells are highly regarded for their potential in tissue repair and regenerative medicine due to their multipotency and self-renewal abilities. Recently, mesenchymal stem cells have been redefined as "medical signaling cells," with their primary biological effects mediated through exosome secretion. These exosomes, which contain lipids, proteins, RNA, and metabolites, are crucial in regulating various biological processes and enhancing regenerative therapies.

View Article and Find Full Text PDF

Exosome-mediated macrophage polarization: Pioneering pathways in diabetic wound healing.

Int Immunopharmacol

August 2025

Department of Hand Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Provincial Clinical Research Center for Chronic Wound and Diabetic Foot,Wuhan, Hubei 430077, China. Electronic address:

Recent studies have identified an essential role of macrophage polarization imbalance in the impaired diabetic wound healing process. Macrophages are key players in wound healing, and their transition from the pro-inflammatory M1 phenotype to the anti-inflammatory and reparative M2 phenotype is crucial for effective wound repair. However, in diabetic conditions, this balance is disrupted, leading to prolonged M1 activation and reduced M2 functionality, which hinders the healing process.

View Article and Find Full Text PDF