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Background: Despite the availability of clinical practice guidelines for temporomandibular disorders (TMDs), research evidence on current clinical practice trends is scarce.
Objective: This study aimed to analyse the TMD treatment trends and patterns according to patient characteristics in Korea over a 9-year period.
Methods: The 2010-2018 Korean Health Insurance Review & Assessment Service National Patient Sample data were used. A total of 109 969 patients diagnosed with TMD as the principal diagnosis at least once in each year were included in the study. The types of visits and treatments were analysed by year. K-medoids clustering was then performed to analyse the treatment patterns according to patient characteristics.
Results: The most commonly used drugs for pharmacological treatment were non-steroidal anti-inflammatory drugs (NSAIDs) and relaxants. The prescription of opioids, anxiolytics and antidepressants was reduced. Among non-pharmacological treatments, physiotherapy was the most utilised, and its use increased over the years. Cluster analysis showed that treatment patterns generally differed between sexes; the rate of outpatient visits and the use of NSAIDs, relaxants and physiotherapy were higher among female patients.
Conclusions: This study showed that TMD treatment prescriptions changed from 2010 to 2018 and found notable trends in NSAIDs, relaxants, opioids, anxiolytics, antidepressants and physiotherapy. Moreover, the treatment patterns differed between the sexes. These findings indicate that the prescriptions for TMD treatment changed over the years; these results may be useful in the development of future clinical guidelines and should be reflected in future guidelines.
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http://dx.doi.org/10.1111/joor.13333 | DOI Listing |
Surg Oncol
September 2025
Department of Gastrointestinal Surgery, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Background: Recently, thoracic duct embolization (TDE) has been increasingly adopted as a first-line minimally invasive therapy for post-esophagectomy chylothorax instead of thoracoscopic thoracic duct ligation (TTDL). However, the therapeutic efficacy and advantages of TDE over TTDL are still controversial. This study aimed to evaluate and compare the clinical and financial outcomes of TDE and TTDL for post-operative chylothorax after esophagectomy using a national database.
View Article and Find Full Text PDFJ Adv Res
September 2025
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, The Fourth Military Medical Univ
Introduction: Aberrant biomechanical force-induced chondrocyte adipogenesis is involved in the development of temporomandibular joint osteoarthritis (TMJ OA). Growth differentiation factor 11 (GDF11) has been implicated in this process. However, whether mechanosensitive histone deacetylase 3 (HDAC3) regulates GDF11 signaling in the context of TMJ OA remains to be elucidated.
View Article and Find Full Text PDFJ Am Dent Assoc
September 2025
Background: In this narrative review, the authors aimed to provide a focused overview, grounded in scientific literature, of the most common primary and secondary headaches frequently observed in patients with orofacial pain as well as orofacial conditions that may mimic primary headache disorders. In addition, they highlighted the clinically significant overlap between headaches and temporomandibular disorders (TMDs).
Types Of Studies Reviewed: Information was sourced from the International Classification of Headache Disorders, Third Edition, for headache diagnoses and from the International Classification of Orofacial Pain for orofacial pain diagnoses.
PLoS One
September 2025
Animal Experiment Center, Sichuan Academy of Chinese Medicine Sciences, ChengDu, SiChuan, China.
Postmenopausal osteoporosis (PMOP) is a common primary osteoporosis. With the aging of the population, it is becoming a major disease that endangers health and quality of life. The purpose of this study was to explore the effect of gut microbiota on PMOP by observing the changes in the levels of estradiol, bone density, and gut microbiota diversity in rats after 3 months of OVX surgery.
View Article and Find Full Text PDFJ Oral Rehabil
September 2025
Postgraduate School of Orthodontics and Gnathology Unit, Department of Surgical Sciences, Dental School, University of Turin, Turin, Italy.
Background And Objective: Cervical spine impairments are frequent findings among patients with temporomandibular disorders (TMDs). Previous studies have demonstrated that treatments targeting the upper cervical region can improve pain symptoms in patients with TMD. The aim of the current study was to assess whether counselling alone and counselling plus occlusal splint therapy can also provide relief for coexisting neck pain.
View Article and Find Full Text PDF