Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Six new β-resorcylic acid derivatives (- and ) were isolated from a halophyte-associated fungus, JS0419, together with four previously reported β-resorcylic acid lactones (RALs). The relative and absolute stereochemistry of was completely established by a combination of spectroscopic data and chemical reactions. The structures of the isolated compounds were elucidated by analysis of HRMS and NMR data. Notably, compounds - had a β-resorcylic acid harboring a long unesterified aliphatic side chain, whereas the long aliphatic chains were esterified to form macrolactones in -. Among the isolated compounds, monocillin I and radicicol showed potent antifungal activities against , comparable to clinically available antifungal agents and radicicol showed weak antifungal activity against . These findings provide insight into the chemical diversity of fungal RAL-type compounds and their pharmacological potential.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951769 | PMC |
| http://dx.doi.org/10.3390/md20030195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Next-Generation Nanoparticle-Enabled mRNA Vaccines in the Treatment of COVID-19.
Crit Rev Ther Drug Carrier Syst
January 2025
The emergence of messenger ribonucleic acid (mRNA) vaccines as an alternative platform to traditional vaccines has been accompanied by advances in nanobiotechnology, which have improved the stability and delivery of these vaccines through novel nanoparticles (NPs). Specifically, the development of NPs for mRNA delivery has facilitated the loading, protection and release of mRNA in the biological microenvironment, leading to the stimulation of mRNA translation for effective intervention strategies. Intriguingly, two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been permitted for emergency usage authorization to prevent COVID-19 infection by USFDA.
View Article and Find Full Text PDFAn ultrasensitive biosensor for H1N1 virus coupled with 3D spherical DNA nanostructure and CRISPR-Cas12a.
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address:
To achieve ultrasensitive and real-time detection of the H1N1 influenza virus, this study designed a nucleic acid-free fluorescent biosensor based on 3D spherical DNA nanostructure and CRISPR/Cas12a (3D-SDNC). The biosensor constructs a rigid 3D nano-framework via self-assembly of six oligonucleotide chains, with H1N1-specific nucleic acid aptamers and Cas12a activator strands strategically positioned at multi-spined vertices for precise spatial coupling between viral recognition and signal transduction. Upon aptamer-virus binding, the induced conformational change liberates the activator strand, thereby activating the trans-cleavage activity of the Cas12a/crRNA complex to efficiently cleave the HEX/BHQ1 double-labeled fluorescent probe and initiate cascade signal amplification.
View Article and Find Full Text PDFDesign and Fabrication of Flexible Silk Fibroin/Lanthanide Ion Membranes with Multifunctional Properties of Fluorescence, Humidity Sensitivity, and Conductivity.
ACS Appl Mater Interfaces
September 2025
College of Chemistry and Chemical Engineering, Instrumental Analysis Center of Qingdao University, Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qing
Silk fibroin (SF)-based flexible electronic/photonic materials have gained great attention in wearable devices and soft sensors. However, it remains challenging to understand the molecular interaction mechanisms and subsequently fabricate SF-based flexible materials that exhibit fluorescence, humidity sensitivity, and conductivity properties. In this study, by incorporating lanthanide europium ion (Eu), the design and fabrication of a flexible, fluorescent, and conductive SF membrane was proposed.
View Article and Find Full Text PDFVisible Light-Driven Benzylic C(sp)-H Carboxylation Enables Synthesis of C-Labeled (±)-α-Amino Acids with C-Formate.
Org Lett
September 2025
Frontiers Science Center for Transformative Molecules, State Key Laboratory of Polyolefins and Catalysis, State Key Laboratory of Synergistic Chem-Bio Synthesis, Zhang Jiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
C-labeled α-amino acids are important molecules in biological studies and drug development. Cost-effective synthesis of α-amino acids with a high level of C incorporation under mild conditions remains limited. Herein, we report the development of a benzylic C(sp)-H carboxylation method to prepare highly C-labeled α-amino acids, i.
View Article and Find Full Text PDFEfficient Production of Mano/Xylo-Oligosaccharides with Excellent Probiotic Activity through Coupling Catalysis.
J Agric Food Chem
September 2025
Department of Chemistry and Chemical Engineering, Engineering Research Center of Forestry Biomass Materials and Bioenergy (Ministry of Education), National Forest and Grass Administration Woody Spices (East China) Engineering Technology Research Center, Beijing Forestry University, Beijing 100083, C
This study develops a catalytic system using pyruvic acid (PYA) and Fe to efficiently coproduce xylo-oligosaccharides (XOS) and (manno-oligosaccharides) MOS from food material ( Lam. fruit.) and its waste peel, respectively.
View Article and Find Full Text PDF