Validity of a smartphone application for self-monitoring psychiatric symptoms in patients with schizophrenia.

Objective: Despite increasing research on digital technologies for psychiatric disorders, studies specifically examining self-monitoring of symptoms with smartphone applications by patients with schizophrenia remain limited. This study aims to evaluate the validity and reliability of self-monitoring psychiatric symptoms using a smartphone application among patients with schizophrenia at Mindlink, a community-based early intervention center.

Methods: Fifty-three young patients with schizophrenia spectrum disorders participated.

Real-Time Unsupervised Learning and Image Recognition via Memristive Neural Integrated Chip Based on Negative Differential Resistance of Electrochemical Metallization Cell Neuron Device.

Spiking neurons are essential for building energy-efficient biomimetic spatiotemporal systems because they communicate with other neurons using sparse and binary signals. However, the achievable high density of artificial neurons having a capacitor for emulating the integrate function of biological neurons has a limit. Furthermore, a low-voltage operation (<1.

Determinants of Length of Stay for Medical Inpatients Using Survival Analysis.

With the increase in insured patients and an aging population, managing the length of stay (LOS) for inpatients has become crucial for controlling medical costs. Analyzing the factors influencing LOS is necessary for effective management. Previous studies often used multiple or logistic regression analyses, which have limitations such as unmet assumptions and the inability to handle time-dependent variables.

A Comparative Study of Hospitalization Mortality Rates between General and Emergency Hospitalized Patients Using Survival Analysis.

Background/objectives: In Korea's emergency medical system, when an emergency patient arises, patients receive on-site treatment and care during transport at the pre-hospital stage, followed by inpatient treatment upon hospitalization. From the perspective of emergency patient management, it is critical to identify the high death rate of patients with certain conditions in the emergency room. Therefore, it is necessary to compare and analyze the determinants of the death rate of patients admitted via the emergency room and generally hospitalized patients.

The residue of salinomycin in the muscles of olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes Schlegeli) after oral administration analyzed by LC-Tandem-MS.

Background: Salinomycin, an antibiotic, have potential as a veterinary drug for fish due to its anti-parasitic activity against several fish parasites. Thus the residual levels of salinomycin in muscles of two significant aquaculture species in Korea, olive flounder and black rockfish, were analyzed using HPLC-MS-MS.

Results: The proper method to analyze the residual salinomycin in fish muscles using LC-MS-MS was settled and the method was validated according to CODEX guidelines.

Assessment of Salinomycin's Potential to Treat in Korean Rockfish ().

Aquaculture, a crucial sector of the global food industry, faces a myriad of issues due to parasitic invasions. One such parasite, , which afflicts Korean rockfish in South Korea, has a significant economic impact. The impending danger of resistance to traditional anthelmintics necessitates the exploration of new antiparasitic candidates.

Discovery of Naphthol Tetramers from Endolichenic Fungus 047219 Based on MS/MS Molecular Networking.

Feature-based molecular networking analysis suggested the presence of naphthol tetramers in 047219, the same species but a different strain from one used previously for the discovery of naphthol trimers promoting adiponectin synthesis. The new tetramers were composed of 5-methoxy-4-naphthol, each of which was connected to one another in various positions. Targeted isolation afforded six previously unreported naphthol tetramers (-) together with 13 known polyketides (-) including naphthol monomers, dimers, and trimers.

New secondary metabolites produced by Paraphoma radicina FB55 as potential antifungal agents.

Microorganisms in specific environments are rich sources of bioactive natural products as they produce compounds that can aid their survival in harsh environments. In an effort to investigate antifungal compounds produced by microorganisms, the fungal strain Paraphoma radicia FB55, isolated from a marine sediment of the Beaufort Sea, north of Alaska, was subjected to chemical investigation. Chromatography of the culture extracts yielded two new compounds (1 and 2) and eight known compounds (3-10).

Discovery of Bioactive Metabolites by Acidic Stress to a Geldanamycin Producer, .

In an effort to activate silent biosynthetic gene clusters, DSM42010, a producer of geldanamycin, was cultured at four different pHs (4.5, 5.4, 6.

New Anti-Inflammatory β-Resorcylic Acid Lactones Derived from an Endophytic Fungus, sp.

The endophytic fungus JS0419, isolated from the leaves of the halophyte , produced four new β-resorcylic acid derivatives, colletogloeopyrones A and B ( and ) and colletogloeolactones A and B ( and ), and seven known β-resorcylic acid lactones (RALs). The structures of these compounds were elucidated via analysis of the high-resolution mass spectrometry and nuclear magnetic resonance data. Compounds and showed a dihydrobenzopyranone ring with a linear C9 side chain, which is rarely observed in RALs.

Discovery of Pan-peroxisome Proliferator-Activated Receptor Modulators from an Endolichenic Fungus, .

Adiponectin-synthesis-promoting compounds possess therapeutic potential to treat diverse metabolic diseases, including obesity and diabetes. Phenotypic screening to find adiponectin-synthesis-promoting compounds was performed using the adipogenesis model of human bone marrow mesenchymal stem cells. The extract of the endolichenic fungus 047215 significantly promoted adiponectin production.

Development and Evaluation of Machine Learning-Based High-Cost Prediction Model Using Health Check-Up Data by the National Health Insurance Service of Korea.

In this study, socioeconomic, medical treatment, and health check-up data from 2010 to 2017 of the National Health Insurance Service (NHIS) of Korea were analyzed. This year's socioeconomic, treatment, and health check-up data are used to develop a predictive model for high medical expenses in the next year. The characteristic of this study is to derive important variables related to the high cost of domestic medical expenses users by using data on health check-up items conducted by the country.

Rare β-Resorcylic Acid Derivatives from a Halophyte-Associated Fungus JS0419 and Their Antifungal Activities.

Six new β-resorcylic acid derivatives (- and ) were isolated from a halophyte-associated fungus, JS0419, together with four previously reported β-resorcylic acid lactones (RALs). The relative and absolute stereochemistry of was completely established by a combination of spectroscopic data and chemical reactions. The structures of the isolated compounds were elucidated by analysis of HRMS and NMR data.

Adiponectin-Secretion-Promoting Cyclic Peptide-Polyketide Hybrids from a Halophyte-Associated Fungus, JS0417.

Three new cyclic peptide-polyketide hybrids (-) and two new chaetiacandin-type polyketides ( and ) along with nine known compounds were isolated from cultures of a halophyte-associated fungus, JS0417. Spectroscopic analysis revealed that - were cyclic depsipeptides where 3,5,11-trihydroxy-2,6-dimethyldodecanoic acid was linked to two amino acids through amide and ester bonds to form a 12-membered ring. Relative and absolute configurations for the peptides were determined with spectroscopic analysis and chemical reactions.

Azaphilones from an Endophytic sp. Prevent Neuronal Cell Death via Inhibition of MAPKs and Reduction of Bax/Bcl-2 Ratio.

Fourteen azaphilone-type polyketides (-), including nine new ones (- and -), were isolated from cultures of -associated sp. JVF17, and their structures were determined by spectroscopic analysis together with computational methods and chemical reactions. Neuroprotective effects of the isolated compounds were evaluated against glutamate-induced neurotoxicity.

Mindlink: A stigma-free youth-friendly community-based early-intervention centre in Korea.

Aim: In many Asian countries, youth mental health services are not well-developed and access to treatment is generally delayed. Here, we present a community-based service model based on our experience with Mindlink, the first early-intervention centre of its kind in Korea.

Methods: We describe the history of this mental health early-intervention service and the characteristics of users, as well as its intervention programmes and research directions.

Bioinspired dual-morphing stretchable origami.

Nature demonstrates adaptive and extreme shape morphing via unique patterns of movement. Many of them have been explained by monolithic shape-changing mechanisms, such as chemical swelling, skin stretching, origami/kirigami morphing, or geometric eversion, that were successfully mimicked in artificial analogs. However, there still remains an unexplored regime of natural morphing that cannot be reproduced in artificial systems by a "single-mode" morphing mechanism.

Validation of the Korean Version of the 15-Item Community Assessment of Psychic Experiences in a College Population.

Objective: To investigate the reliability and validity of the Korean version of the Community Assessment of Psychic Experiences-15 item positive scale (CAPE-15) in college students.

Methods: This study had two stages: initial screening with self-report questionnaires including the CAPE-15, and semi-structured interviews to investigate the instrument's diagnostic validity. The initial screening involved 1,749 college students.

Evaluation of subjective perceived rating for grip strength depending on handedness for various target force levels.

Background: Measurement of hand exertion is very important to quantify the risk of Work-related Musculoskeletal Disorders (WMSDs) in manufacturing fields. Although a direct measurement is the most accurate way to quantify physical load, it is expensive and time consuming. To solve this limitation, a subjective self-report method has been proposed as a possible alternative.

Validation of the Korean version of the 16-Item Prodromal Questionnaire in a Non-Help-Seeking College Population.

Objective: To examine the reliability and validity of the Korean version of the 16-item Prodromal Questionnaire (KPQ-16) in non-help-seeking university students.

Methods: Among 2,246 university students participated in the initial screening, 257 subjects with KPQ-16 scores ≥4 were interviewed. The criteria for ultra-high risk (UHR) of psychosis of the Comprehensive Assessment of At-Risk Mental States (CAARMS) were the gold standard for diagnosis.