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Introduction: Pneumorrhachis is a rare clinical entity that is usually asymptomatic. Previous reports have associated such events with epidural insertion using a loss of resistance (LOR) to air technique. This report describes a case of symptomatic epidural pneumorrhachis following epidural anaesthesia using LOR to saline.
Case Report: A 32-year-old American Society of Anesthesiologists (ASA) Classification II female patient was admitted for unplanned caesarean section. Epidural anaesthesia was performed at the L3-4 space using LOR to saline. The procedure, including delivery of the neonate, was uneventful. In the recovery room, a local anaesthetic infusion via an elastomeric pump (infusion 'balloon') was started. Two hours after initiation of the infusion the patient complained of motor blockade, so it was stopped. Two hours later she remained paraparetic, and a neurologist assessment was required. A computed tomography scan showed epidural pneumorrhachis at the L2-3 level. The patient was referred for emergent hyperbaric oxygen treatment (US Navy Treatment Table 5) and following one session the patient recovered completely.
Discussion: Anaesthetists should be aware of this rare complication, which is easily overlooked. Hyperbaric oxygen treatment is a first line treatment for gas-associated lesions with neurological impairment. Timely referral is essential to prevent irreversible deficits.
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http://dx.doi.org/10.28920/dhm52.1.54-57 | DOI Listing |
Zhonghua Nan Ke Xue
July 2025
Reproduction Medicine Center, General Hospital of Northern Theater Command, Shenyang, Liaoning 110003, China.
Objective: To investigate the relationship among seminal oxidation-reduction potential (nORP), sperm DNA fragmentation (DFI) and semen parameters in patients with varicocele.
Methods: Clinical data of 522 patients treated in the reproductive andrology clinic of the Northern Theater General Hospital from November 2023 to December 2023 were retrospectively analyzed, including 435 men of childbearing age and 87 men of infertile age. The patients were divided into the varicocele group (n=116) and non-varicocele group (n=406) according to clinical diagnosis.
Ulus Travma Acil Cerrahi Derg
September 2025
Department of General Surgery, Gülhane Faculty of Medicine, University of Health Sciences, Ankara, Türkiye.
Background: This retrospective cohort study aimed to evaluate the safety of hyperbaric oxygen therapy (HBOT) in patients with blunt thoracic trauma, with particular focus on crush injuries sustained during the 2023 Kahramanmaraş earthquakes.
Methods: Twenty-five patients with documented thoracic trauma who underwent HBOT at a tertiary care center were included. HBOT was delivered at 2.
Mol Med Rep
November 2025
Emergency Department, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China.
Sudden sensorineural hearing loss (SSNHL) is an acute hearing disorder that develops rapidly and is an otolaryngology emergency. Hyperbaric oxygen therapy (HBOT), a non‑pharmacological treatment, has gained increasing attention for SSNHL management. HBOT exerts therapeutic effects by increasing inner ear oxygen partial pressure, improving the microcirculation and reducing inflammation, as its main mechanisms.
View Article and Find Full Text PDFPLoS One
September 2025
Beijing Engineering Research Center of Industrial Spectrum Imaging, School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing, China.
There is limited evidence on how social determinants of health (SDOH) and physical frailty (PF) influence mortality prediction in heart failure (HF), particularly for in-hospital, 90-day, and 1-year outcomes. This study aims to develop explainable machine learning (ML) models to assess the prognostic value of SDOH and PF at multiple time points. We analyzed data from adult patients admitted to the intensive care unit (ICU) for the first time with a diagnosis of HF.
View Article and Find Full Text PDFFront Immunol
September 2025
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China.
Rheumatoid Arthritis (RA) is an autoimmune disease caused by many factors, with a high disability rate, unsatisfactory clinical treatment effect, and unclear pathogenesis. The oxygen level in the joint cavity is significantly reduced, and the hypoxic microenvironment has become a key factor in the pathogenesis and progression of RA. Based on the latest research developments, this review delves into the structure and main functions of the key factor HIF in the hypoxic microenvironment, and expounds the main regulatory mechanisms of HIF.
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