Microvascular, Biochemical, and Clinical Impact of Hyperbaric Oxygen Therapy in Recalcitrant Diabetic Foot Ulcers.

Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes and are often difficult to treat. Hyperbaric oxygen therapy (HBOT) has been proposed as an adjunctive treatment to promote healing, but its long-term clinical and biological effects remain insufficiently characterized. This study aimed to evaluate the impact of HBOT on systemic biomarkers, local microvasculature, and clinical outcomes in patients with DFUs.

Active hand inflammation. Differing clinical and ultrasound patterns in patients with rheumatoid arthritis and psoriatic arthritis - A cross-sectional, multicenter study.

Objectives: To define ultrasound (US) characteristics in patients with Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) exhibiting active hand inflammation.

Methods: This cross-sectional, multicenter study collected epidemiological and clinical data from RA and PsA patients with active hand inflammation. US examinations of wrists and metacarpophalangeal joints were performed, focusing on extensor and flexor tendons.

Phosphorylation in the Proteome: A Meta-Analysis of Publicly Available Data Sets.

Malaria is a deadly disease caused by Apicomplexan parasites of the genus. Several species of the genus are known to be infectious to humans, of which is the most virulent. Post-translational modifications (PTMs) of proteins coordinate cell signaling and hence regulate many biological processes in homeostasis and host infection, of which the most highly studied is phosphorylation.

Outcomes for Female Physicians Compared With Nonphysicians After Assisted Reproductive Technology.

Objective: To evaluate outcomes of female physicians after assisted reproductive technology (ART).

Methods: We conducted a retrospective cohort study using data from 248 physician patients and 3,470 nonphysician patients who underwent a total of 10,095 fresh or frozen ART cycles at a single academic center in an insurance-mandated state between January 2015 and March 2022. The primary outcome was live-birth rate.

Hyperbaric oxygen therapy in the treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Introduction: Hemorrhagic cystitis (HC) is a common complication after allogeneic hematopoietic stem cell transplantation (HSCT), characterized by inflammation and bleeding of the bladder. Hyperbaric oxygen therapy (HBOT) has been shown to be effective in the treatment of radiation-induced HC. However, the optimal treatment for HC after allogeneic HSCT has not yet been established.

Ultrasound Evaluation of Soft Tissue Masses and Parotid Gland in Clinical Rheumatology.

Soft tissue masses are very common and may appear in the context of rheumatic diseases. They usually occur alone but may occasionally be part of the syndromes and can sometimes involve periarticular tissues. Soft tissue masses can be divided into several categories.

Effects of Hyperbaric Oxygen Therapy in the Treatment of Patients With Central Retinal Artery Occlusion: A Retrospective Study.

Background Central retinal artery occlusion (CRAO) results in sudden, painless vision loss. As an analogous condition to acute ischemic stroke, CRAO is an ophthalmological emergency, but a standardized treatment is lacking. Hyperbaric oxygen therapy (HBOT) has been widely used in spite of the inconsistent results reported.

A Hybrid Control Framework for Chemical Processes with Long Time Delay: Theory and Experiments.

This paper proposes a hybrid control framework based on internal model concepts, sliding mode control methodology, and fractional-order calculus theory. As a result, a modified Smith predictor (SP) is proposed for nonlinear systems with significant delays. The particular predictive approach enhances the sliding mode control (SMC) controller's transient responses for dead-time processes, and the SMC gives the predictive structure robustness for model mismatches by combining the previous methods with fractional order concepts; the result is a dynamical sliding mode controller.

Meta-Analysis of Rice Phosphoproteomics Data to Understand Variation in Cell Signaling Across the Rice Pan-Genome.

Phosphorylation is the most studied post-translational modification, and has multiple biological functions. In this study, we have reanalyzed publicly available mass spectrometry proteomics data sets enriched for phosphopeptides from Asian rice (). In total we identified 15,565 phosphosites on serine, threonine, and tyrosine residues on rice proteins.

Hyperbaric oxygen therapy in malignant otitis externa: a retrospective analysis.

Purpose: Malignant otitis externa (MOE) is a rare form of invasive osteomyelitis of the external ear canal. It is typically caused by Pseudomonas aeruginosa in immunocompromised patients. The diagnosis is clinical, and the initial treatment involves systemic antibiotics or antifungal therapy.

Utility of applying a diagnostic algorithm in giant cell arteritis based on the level of clinical suspicion.

Introduction: To reach the diagnosis of giant cell arteritis (GCA), signs, symptoms, laboratory tests, imaging findings, and occasionally anatomopathological results from temporal artery biopsy are evaluated. This study describes the results of an algorithm analysis based on clinical and ultrasound evaluation of patients with suspected GCA, highlighting its diagnostic utility by contrasting its use in different clinical suspicion scenarios.

Method: Prospective multicenter study evaluating patients referred with suspected GCA through a preferential circuit (fast track), grouping them according to low or high clinical suspicion of GCA.

A meta-analysis of rice phosphoproteomics data to understand variation in cell signalling across the rice pan-genome.

Phosphorylation is the most studied post-translational modification, and has multiple biological functions. In this study, we have re-analysed publicly available mass spectrometry proteomics datasets enriched for phosphopeptides from Asian rice (). In total we identified 15,522 phosphosites on serine, threonine and tyrosine residues on rice proteins.

Hybrid Controller Based on Numerical Methods for Chemical Processes with a Long Time Delay.

A hybrid control framework is proposed as an alternative for long time delays in chemical processes. The hybrid approach mixes the numerical methods in an internal mode control (IMC) structure, which uses the particle swarm optimization (PSO) algorithm to improve the adjustment of the controller parameters. Simulation tests are carried out on linear systems of high order and inverse response, both with dominant delay, and tests on a nonlinear process (chemical reactor).

Assessing Multiple Evidence Streams to Decide on Confidence for Identification of Post-Translational Modifications, within and Across Data Sets.

Phosphorylation is a post-translational modification of great interest to researchers due to its relevance in many biological processes. LC-MS/MS techniques have enabled high-throughput data acquisition, with studies claiming identification and localization of thousands of phosphosites. The identification and localization of phosphosites emerge from different analytical pipelines and scoring algorithms, with uncertainty embedded throughout the pipeline.

Dual-Mode Based Sliding Mode Control Approach for Nonlinear Chemical Processes.

This paper synthesizes a new sliding mode controller (SMC) approach to enhance tracking and regulation tasks by following dual-mode concepts. The new control law consists of two distinct types of operation, using the combination of higher gain to large error signals (transient) and lower gain to small error signals (the region around the set point). The design is presented from a dual-mode (PD-PID) sliding surface operating in concert, fulfilling desired control objectives to ensure stability and performance.

Cerebral Air Embolism Following Transthoracic Lung Biopsy Successfully Treated With Hyperbaric Oxygen.

Transthoracic lung biopsy is a frequently performed procedure performed worldwide. Although rare, air embolism is a potentially fatal complication. Rapid diagnosis and immediate treatment are essential to prevent patient clinical deterioration.

Hybrid Approaches-Based Sliding-Mode Control for pH Process Control.

This paper presents two hybrid control topologies; the topologies are designed by combining artificial intelligence approaches and sliding-mode control methodology. The first topology mixes the learning algorithm for multivariable data analysis (LAMDA) approach with sliding-mode control. The second offers a Takagi-Sugeno multimodel approach, internal model, and sliding-mode control.

The role of hyperbaric oxygen therapy in the treatment of radiation lesions.

Introduction: Cancer remains one of the leading causes of death worldwide, with 50-60% of patients requiring radiotherapy during the course of treatment. Patients' survival rate has increased significantly, with an inevitable increase in the number of patients experiencing side effects from cancer therapy. One such effect is late radiation injuries in which hyperbaric oxygen therapy appears as complementary treatment.

Method for Independent Estimation of the False Localization Rate for Phosphoproteomics.

Phosphoproteomic methods are commonly employed to identify and quantify phosphorylation sites on proteins. In recent years, various tools have been developed, incorporating scores or statistics related to whether a given phosphosite has been correctly identified or to estimate the global false localization rate (FLR) within a given data set for all sites reported. These scores have generally been calibrated using synthetic datasets, and their statistical reliability on real datasets is largely unknown, potentially leading to studies reporting incorrectly localized phosphosites, due to inadequate statistical control.

A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products.

Nicotine replacement therapies (NRTs) are intended for short-term use to help cigarette smokers to quit. Some smokers find NRTs ineffective or seek a more satisfactory source of nicotine. Tobacco-free oral nicotine pouch (NP) products have emerged as a potential reduced risk product compared with cigarettes and other tobacco products.

Abnormal motor blockade after epidural analgesia caused by pneumorrhachis and the role of hyperbaric oxygen treatment: a case report.

Introduction: Pneumorrhachis is a rare clinical entity that is usually asymptomatic. Previous reports have associated such events with epidural insertion using a loss of resistance (LOR) to air technique. This report describes a case of symptomatic epidural pneumorrhachis following epidural anaesthesia using LOR to saline.