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Sepsis is the major culprit of death among critically ill patients who are hospitalized in intensive care units (ICUs). Although sepsis-related mortality is steadily declining year-by-year due to the continuous understanding of the pathophysiological mechanism on sepsis and improvement of the bundle treatment, sepsis-associated hospitalization is rising worldwide. Surviving Sepsis Campaign (SSC) guidelines are continuously updating, while their content is extremely complex and comprehensive for a precisely implementation in clinical practice. As a consequence, a standardized step-by-step approach for the diagnosis and treatment of sepsis is particularly important. In the present study, we proposed a standardized step-by-step approach for the diagnosis and treatment of sepsis using our daily clinical experience and the latest researches, which is close to clinical practice and is easy to implement. The proposed approach may assist clinicians to more effectively diagnose and treat septic patients and avoid the emergence of adverse clinical outcomes.
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http://dx.doi.org/10.1177/08850666221085181 | DOI Listing |
Zhonghua Kou Qiang Yi Xue Za Zhi
September 2025
Department of Periodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stoma
The periodontal chart comprehensively and objectively records the periodontal status of each tooth in the entire dentition, which is an important basis and essential for the correct diagnosis of periodontal diseases and treatment plan formulation. This article describes in detail the content and clinical significance of the periodontal chart, the key points of the implementation of the clinical completion of the periodontal chart and the step-by-step training mode. This article, as the fourth chapter in the basic skills training series for periodontal diagnosis and treatment, aims to provide guidance for the standardization of periodontal chart recording and application in the clinic and teaching, so as to promote the standardization of Chinese periodontal diagnosis and treatment and bring it on par with the international advanced level.
View Article and Find Full Text PDFVideo J Sports Med
August 2025
Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo-SP, Brazil.
Background: Medial patellofemoral ligament (MPFL) reconstruction is the main procedure performed for recurrent patellar instability. Choosing wisely between graft options is particularly important in this specific population, who often lacks neuromuscular control. The gracilis, semitendinosus, and quadriceps tendons are the most frequently used autografts, but harvesting can lead to reduced thigh muscle strength and poorer balance control.
View Article and Find Full Text PDFArthroplast Today
October 2025
Fondren Orthopedic Research Institute, Fondren Orthopedic Group, Houston, TX, USA.
Inverse kinematic alignment (iKA) is an emerging technique in total knee arthroplasty (TKA) that aims to restore the patients' native tibial joint line obliquity with femoral resections adjusted to balance the knee. By emphasizing joint line restoration and patient-specific balancing, iKA has gained interest as a potentially favorable alternative to traditional alignment techniques. This step-by-step surgical technique aims to outline the essential principles of iKA in robotic-assisted TKA.
View Article and Find Full Text PDFCard Electrophysiol Clin
September 2025
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Center for Outcomes Research and Evaluation, Yale New Haven Hospital, 195 Church Street, 6th Floor, New Haven, CT 06510, USA. Electronic address:
Invasive or selective pulmonary angiography has historically been used as the gold standard diagnostic test for the evaluation of a wide array of pulmonary arterial conditions, most commonly pulmonary thromboembolic diseases. With the emergence of various noninvasive imaging modalities, the role of invasive pulmonary angiography is shifting to the assistance of advanced pharmacomechanical therapies for such conditions. Components of invasive pulmonary angiography methodology include optimal patient positioning, vascular access, catheter selections, angiographic positioning, contrast settings, and recognition of angiographic patterns of common thromboembolic and nonthromboembolic conditions.
View Article and Find Full Text PDFComput Methods Programs Biomed
November 2025
Institute of Systems Science and Technology, School of Electrical Engineering, Southwest Jiaotong University, Chengdu 611756, China. Electronic address:
Background: Laparoscopic cholecystectomy is the gold standard procedure for the treatment of benign gallbladder diseases, but there is the risk of intraoperative bile duct injury, which can lead to surgical failure and cause significant social and economic burden. When surgeons rely on visual inspection to identify tissue structures during laparoscopic cholecystectomy, subjective factors such as experience, psychological factors, and fatigue can compromise the intraoperative recognition of anatomic landmarks. The positioning of anatomical landmarks by the surgeon in the pre-dissection phase of laparoscopic cholecystectomy is relatively vague and requires step-by-step exploration as the surgery progresses, becoming clearer in the post-dissection phase.
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