Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate ( L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various and model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8885183 | PMC |
| http://dx.doi.org/10.1155/2022/3848084 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Scoping Review of Chemical, Pharmacological and Toxicological Properties and Clinical Applications of Australian Indigenous Medicine.
Biomed Pharmacother
September 2025
NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia. Electronic address:
Indigenous Australians have long recognised and utilised the therapeutic potential of Australian native plants for generations to treat and manage various diseases. In recent years, these native plants have been explored in preclinical research for their chemical profiles and therapeutic properties for conditions such as skin disorders, colds and flu, various cancers, neurological disorders, metabolic syndrome, and other inflammatory conditions. Notable species studied include Kakadu plum, Davidson's plum, Burdekin plum, Illawarra plum, anise myrtle, lemon myrtle, lemon aspen, quandong, muntries, and Tasmanian pepperberry.
View Article and Find Full Text PDFEllagic Acid Promotes Lipid Reduction in High-Fat Diet-Induced Obese Mice by Remodeling the Gut Microbiota and Activating PPAR Pathways and Retinol Metabolism in Adipose Tissue.
Mol Nutr Food Res
September 2025
Institute of Nutrition and Health, Qingdao University, Qingdao, People's Republic of China.
Ellagic acid (EA), a bioactive polyphenol abundant in pomegranate and berries, exhibits potential in metabolic regulation. This study investigates EA's anti-obesity mechanisms, focusing on its effects on gut microbiota and transcriptional regulation in adipose tissue. After a 9-week high-fat diet feeding, mice were divided into groups and treated with low-dose EA (10 mg/kg/day), high-dose EA (30 mg/kg/day), or urolithin A (20 mg/kg/day) for 7 weeks, with healthy and obese controls included.
View Article and Find Full Text PDFZinc ions coordinated carboxymethyl chitosan hydrogel doped with ellagic acid for accelerative diabetic wound healing.
Int J Biol Macromol
September 2025
Department of Otorhinolaryngology Head and Neck Surgery, Guangzhou Twelfth People's Hospital (The Affiliated Twelfth People's Hospital of Guangzhou Medical University), Guangzhou Medical University, Guangzhou 510620, China. Electronic address:
Diabetic wound healing remains a critical clinical challenge due to persistent inflammation derived from long-term hyperglycemia. To address this challenge, we reported a zinc ion coordinated CMCS hydrogel for pH responsive delivery of ellagic acid to fulfill diabetic wound management. The incorporation of zinc ions and EA reinforce the hydrogel network via coordination and hydrogen bonding, and confer a pH-responsive release of EA under simulative wound microenvironment.
View Article and Find Full Text PDFUltrastructural Characterization and Pathogenicity of Allovohlkamfia spelaea in a Murine Model: Neuropulmonary Infections and therapeutic Potential of Ellagic Acid.
Exp Parasitol
September 2025
Department of Medical Parasitology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt. Electronic address:
Background: Allovahlkampfia spelaea (A. spelaea) is a free-living amoeba that has recently been recognized to cause Acanthamoeba-like keratitis, the treatment of which is complex. The pathogenic potential of Allovahlkampfia spp.
View Article and Find Full Text PDFDevelopment, Molecular Docking, and Anti-Anemia Potential of Polyherbal Formulation.
Biology (Basel)
August 2025
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Anemia remains a widespread public health concern, and the search for interventions demonstrating potent anti-anemic activity is critical for reducing its impact among high-risk populations. Conventional iron therapies are associated with several complications and potential adverse effects. This study explored a polyherbal approach to develop a safer and more effective alternative treatment for anemia.
View Article and Find Full Text PDF