Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129090PMC
http://dx.doi.org/10.1093/brain/awac038DOI Listing

Publication Analysis

Top Keywords

genotype-phenotype correlations
4
correlations scn8a-related
4
scn8a-related epilepsy
4
epilepsy cohort
4
cohort study
4
study chinese
4
chinese children
4
children southern
4
southern china
4
genotype-phenotype
1

Similar Publications

Intergenerational continuity of depressive symptoms: genetic and environmental pathways.

Psychol Med

September 2025

Faculty of Behavioral and Social Sciences, Department of Pedagogy and Educational Sciences, https://ror.org/012p63287University of Groningen, Groningen, The Netherlands.

Background: Depression runs in families, with both genetic and environmental mechanisms contributing to intergenerational continuity, though these mechanisms have often been studied separately. This study examined the interplay between genetic and environmental influences in the intergenerational continuity of depressive symptoms from parents to offspring.

Methods: Using data from the Dutch TRAILS cohort ( = 2201), a prospective, genetically informed, multiple-generation study, we examined the association between parents' self-reported depressive symptoms (reported at mean age of 41 years) and offspring depressive symptoms, self-reported nearly two decades later, in adulthood (mean age: 29 years).

View Article and Find Full Text PDF

This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024. Eligible studies included observational or interventional designs reporting APN in intact teeth of individuals with SCD.

View Article and Find Full Text PDF

Epithelial ovarian cancer (EOC) remains a leading cause of gynecologic cancer mortality, with high rates of recurrence and chemoresistance. Advances in understanding the molecular biology of EOC, particularly BRCA mutations and homologous recombination deficiency (HRD), have led to more targeted therapies. This review provides an updated summary of systemic treatments for EOC, with an emphasis on personalized therapy approaches and emerging therapeutic strategies.

View Article and Find Full Text PDF

Introduction: Inflammatory cytokine disturbance is a prominent outcome of immune dysregulation, extensively documented in bipolar disorder (BD). However, observational studies have exhibited inconsistent findings, and the causal relationships between inflammatory factors and BD remain unclear. Hence, this study aimed to uncover the causality between circulating inflammatory cytokines and BD.

View Article and Find Full Text PDF

Impact of chorionic villus sampling volume on time to result and pregnancy management.

J Matern Fetal Neonatal Med

December 2025

Section of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: To evaluate the association between low-volume chorionic villus sampling (CVS) and delay in patient care.

Methods: This is a retrospective cohort study of patients who underwent CVS from 8/19/2019 to 12/31/2022 in a single center. The exposure was low-volume CVS, defined as less than 15 mg of sample.

View Article and Find Full Text PDF