Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986667 | PMC |
| http://dx.doi.org/10.1007/s12020-021-02954-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The STUB1-TPIT axis regulates the secretion of adrenocorticotrophic hormone in cushing disease.
J Transl Med
August 2025
Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
Background: Cushing's disease (CD) is a clinical syndrome caused by excessive secretion of adrenocorticotropic hormone (ACTH) from a pituitary corticotroph adenoma, resulting in adrenal cortical hyperplasia and overproduction of cortisol. The T-box transcription factor (TPIT) is crucial for regulating ACTH secretion in pituitary corticotroph adenomas. This study aims to explore the ubiquitin-mediated degradation of TPIT and identify potential pharmaceutical agents for treating CD.
View Article and Find Full Text PDFRapid Adrenal Atrophy Following Excision of an Ectopic Adrenocorticotropin-Secreting Lung Carcinoid Tumor.
JCEM Case Rep
October 2025
Division of Diabetes, Endocrinology and Metabolism, Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK.
Ectopic adrenocorticotropin (ACTH) secretion, a rare cause of ACTH-dependent Cushing syndrome, may be caused by neuroendocrine tumors (NETS). Postoperative hypothalamic-pituitary-adrenal (HPA) axis suppression is expected due to prolonged ACTH and cortisol overproduction. Pituitary corticotrophs are suppressed, but the adrenals are hyperplastic, and cortisol is expected to rise exuberantly after ACTH stimulation.
View Article and Find Full Text PDFRelapse of Cyclic Cushing Syndrome With a 19-Year Remission: Potential Involvement of COVID-19 in the Relapse.
JCEM Case Rep
October 2025
Department of Metabolic Medicine, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.
Cyclic Cushing syndrome (cyclic CS) is characterized by phases of hypercortisolemia and normocortisolemia or hypocortisolemia. Here, we present the first case of cyclic CS with a relapse following COVID-19 infection and a long-term normocortisolemic phase of 19 years. The patient developed CS at the age of 30.
View Article and Find Full Text PDFCongress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Role of Medical Perioperative Management for Patients With Functioning Pituitary Adenomas.
Neurosurgery
August 2025
Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Background And Objectives: Standardized perioperative management of patients with functioning pituitary adenomas is important for optimal medical and surgical outcomes. Review of the literature to evaluate the impacts of (1) postoperative fluid restriction and sodium level checks to prevent delayed hyponatremia and hospital-related readmissions, (2) preoperative somatostatin analog (SSA) medical treatment in patients with growth hormone-secreting tumors and its effects on surgical and medical outcomes, and (3) immediate postoperative pituitary hormone testing in patients with adrenocorticotropic hormone (ACTH)-secreting tumors to predict adrenal insufficiency and disease remission.
Methods: Systematic literature search using Embase and PubMed from 1946 to June 2021.
Successful treatment of Cushing's disease in a pediatric patient with Gamma Knife radiosurgery: a case report.
Ann Med Surg (Lond)
August 2025
School of Medicine, The Maldives National University, Malé, Maldives.
Introduction: Cushing's disease in young-onset cases is a rare and diagnostically challenging endocrinopathy, most commonly caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Early recognition and management are crucial to preventing long-term complications associated with hypercortisolism. This report highlights the case of a pediatric patient with Cushing's disease, emphasizing diagnostic challenges and treatment considerations.
View Article and Find Full Text PDF