98%
921
2 minutes
20
According to the machining characteristics of ceramic-particle-reinforced metal matrix composites, an experimental study on difficult-to-machine materials was carried out by two-dimensional (2D) rotatory ultrasonic combined electrolytic generating machining (RUCEGM), which organically combined an ultrasonic effect with a high-speed rotating tool electrode and electrolysis. After building the one-dimensional (1D) and 2D-RUCEGM systems, the factors influencing the combined machining process were analyzed and the experiments on RUCEGM were conducted to explore the feasibility and advantages of 2D-RUCEGM. The experimental results showed that, compared with 1D-RUCEGM, 2D-RUCEGM had higher accuracy, which increased about 21% and also reduced the machining time. Under certain conditions, the efficiency of 2D-RUCEGM was proportional to the voltage, and the machining efficiency could be enhanced by increasing the feed rate. The inter-electrode voltage detection module used in the experiment could improve the machining stability of the system.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8839304 | PMC |
http://dx.doi.org/10.3390/s22030877 | DOI Listing |
Glob Chang Biol
September 2025
Chair of Silviculture, Faculty of Environment and Natural Resources, Institute of Forest Sciences, University of Freiburg, Freiburg, Germany.
Mixed-species forests are proposed to enhance tree resistance and resilience to drought. However, growing evidence shows that tree species richness does not consistently improve tree growth responses to drought. The underlying mechanisms remain uncertain, especially under unprecedented multiyear droughts.
View Article and Find Full Text PDFJ Intern Med
September 2025
Department of Cellular and Translational Physiology, Institute of Physiology, Ruhr University Bochum, Bochum, Germany.
Background: High-density lipoprotein (HDL) function, rather than its concentration, plays a crucial role in the development of coronary artery disease (CAD). Diminished HDL antioxidant properties, indicated by elevated oxidized HDL (nHDL) and diminished paraoxonase-1 (PON-1) activity, may contribute to vascular dysfunction and inflammation. Data on these associations in CAD patients, including acute coronary syndrome (ACS), remain limited.
View Article and Find Full Text PDFFront Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
Front Immunol
September 2025
Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Introduction: Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a neuropsychiatric disorder with additional psychiatric features caused by NMDA-R immunoglobulin G (IgG) antibodies in cerebrospinal fluid (CSF). This report presents the follow-up of a patient in whom we assumed mild NMDA-R encephalitis in the first psychotic episode.
Case Study: A patient with a prior episode of an acute polymorphic psychotic syndrome relapsed five and a half years later following a severe COVID-19 infection.
Nat Sci Sleep
September 2025
Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Key Laboratory of Elderly Health; Tianjin Geriatrics Institute, Tianjin, People's Republic of China.
Background: Sleep and frailty are established influencing factors for cardiometabolic diseases (CMDs). However, their joint effects on cardiometabolic multimorbidity (CMM) in older adults remain poorly understood. This study aimed to assess the joint effect of sleep health and frailty on CMD prevalence and severity, with an emphasis on subgroup-specific health risk profiles.
View Article and Find Full Text PDF