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http://dx.doi.org/10.1161/JAHA.121.024590 | DOI Listing |
Physiol Plant
September 2025
College of Life Science, Sichuan Agricultural University, Ya'an, China.
Cadmium telluride quantum dots (CdTe QDs) have been increasing in the environment because of their large application in solar panels and biological industries. However, the potential role and bioaccumulation behavior of CdTe QDs in plants are unknown. Herein, the toxicity of CdTe QDs on the growth and the underlying mechanisms were explored in rice.
View Article and Find Full Text PDFAnn Geriatr Med Res
September 2025
Geriatric Education and Research Institute, Singapore.
Objective: To ascertain the construct validity and reliability of a self-administered web-based assessment of intrinsic capacity (IC).
Design: Cross-sectional data analysis of a prospective cohort study.
Settings And Participants: We included data from 6,434 respondents (age, mean (SD): 65.
Viruses
August 2025
Microbiology Department, Multidisciplinary Research Center of Antimicrobial Resistance, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
: Romania has experienced the highest measles incidence rate in the European Union since late 2023, driven by suboptimal measles-mumps-rubella (MMR) uptake. Contemporary data on bedside predictors of clinical deterioration are scarce. The objective was to characterise demographic, clinical and laboratory differences between severe and non-severe measles and derive a multivariable model for intensive-care-unit (ICU) admission.
View Article and Find Full Text PDFBMJ Ment Health
August 2025
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Question: How effective is pharmacogenomic (PGx)-guided antidepressant treatment compared with treatment-as-usual (TAU) in major depressive disorder (MDD), and how do ethnicity, disease severity and genetic panel scope influence outcomes?
Study Selection And Analysis: This systematic review and meta-analysis comprised 13 randomised controlled trials (2013-2024) comparing PGx-guided therapy with TAU in MDD. PubMed, Ovid Embase, Ovid Medline, Ovid PsycINFO and the Cochrane Library were searched up to December 2024. Outcomes included response and remission rates at 8 and 12 weeks.
Health Serv Res
August 2025
Regulatory Science Lab, BC Cancer Research Institute, Vancouver, British Columbia, Canada.
Objective: To determine the effectiveness and cost-effectiveness of multi-gene panel sequencing compared to single-gene KRAS testing for metastatic colorectal cancer (mCRC).
Study Setting And Design: British Columbia, Canada (BC) is a provincial single-payer public healthcare system, and it was the first province to publicly reimburse multi-gene sequencing for mCRC. Panels expand treatment de-escalation by expanding RAS testing for more precise targeting of anti-EGFR therapies.