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It is necessary to improve the performance of some special classes or to particularly protect them from attacks in adversarial learning. This article proposes a framework combining cost-sensitive classification and adversarial learning together to train a model that can distinguish between the protected and unprotected classes, such that the protected classes are less vulnerable to adversarial examples. We find in this framework an interesting phenomenon during the training of deep neural networks, called the Min-Max property, that is, the absolute values of most parameters in the convolutional layer approach 0 while the absolute values of a few parameters are significantly larger, becoming bigger. Based on this Min-Max property which is formulated and analyzed in a view of random distribution, we further build a new defense model against adversarial examples for adversarial robustness improvement. An advantage of the built model is that it performs better than the standard one and can combine with adversarial training to achieve improved performance. It is experimentally confirmed that, regarding the average accuracy of all classes, our model is almost as same as the existing models when an attack does not occur and is better than the existing models when an attack occurs. Specifically, regarding the accuracy of protected classes, the proposed model is much better than the existing models when an attack occurs.
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http://dx.doi.org/10.1109/TCYB.2022.3146388 | DOI Listing |
Comput Methods Biomech Biomed Engin
September 2025
Institute of Radio Physics and Electronics, University of Calcutta, Kolkata, India.
Parkinson's disease (PD) is a neurodegenerative condition that impairs motor functions. Accurate and early diagnosis is essential for enhancing well-being and ensuring effective treatment. This study proposes a deep learning-based approach for PD detection using EEG signals.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Background: Integrated mode proton imaging is a clinically accessible method for proton radiographs (pRads), but its spatial resolution is limited by multiple Coulomb scattering (MCS). As the amplitude of MCS decreases with increasing particle charge, heavier ions such as carbon ions produce radiographs with better resolution (cRads). Improving image resolution of pRads may thus be achieved by transferring individual proton pencil beam images to the equivalent carbon ion data using a trained image translation network.
View Article and Find Full Text PDFJ Chem Phys
September 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, 5735 S. Ellis Ave., SCL 123, Chicago, Illinois 60637, USA.
Molecular dynamics simulations are essential for studying complex molecular systems, but their high computational cost limits scalability. Coarse-grained (CG) models reduce this cost by simplifying the system, yet traditional approaches often fail to maintain dynamic consistency, compromising their reliability in kinetics-driven processes. Here, we introduce an adversarial training framework that aligns CG trajectory ensembles with all-atom (AA) reference dynamics, ensuring both thermodynamic and kinetic fidelity.
View Article and Find Full Text PDFACS Omega
September 2025
Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
Dengue virus remains a significant global health threat, imposing a substantial disease burden on nearly half of the world's population. The urgent need for effective antiviral therapeutics, including therapeutic peptides targeting the Dengue virus, is critical in the current healthcare landscape. However, the availability of anti-Dengue peptides (ADPs) data remains limited in existing data sets, posing a challenge for computational modeling and discovery.
View Article and Find Full Text PDFBiomed Eng Lett
September 2025
Computer Science and Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro. Nam-Gu, Pohang, Gyeongbuk 37673 Korea.
Generative models have become innovative tools across various domains, including neuroscience, where they enable the synthesis of realistic brain imaging data that captures complex anatomical and functional patterns. These models, such as Variational Autoencoders (VAEs), Generative Adversarial Networks (GANs), and diffusion models, leverage deep learning to generate high-quality brain images while maintaining biological and clinical relevance. These models address critical challenges in brain imaging, e.
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