Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Hypovitaminosis D has been suggested to play a possible role in coronavirus disease 2019 (COVID-19) infection.
Methods: The aim of this study is to analyze the relationship between vitamin D status and a biochemical panel of inflammatory markers in a cohort of patients with COVID-19. A secondary endpoint was to evaluate the correlation between 25OHD levels and the severity of the disease. Ninety-three consecutive patients with COVID-19-related pneumonia were evaluated from March to May 2020 in two hospital units in Pisa, in whom biochemical inflammatory markers, 25OHD levels, P/F ratio at nadir during hospitalization, and complete clinical data were available.
Results: Sixty-five percent of patients presented hypovitaminosis D (25OHD ≤ 20 ng/ml) and showed significantly higher IL-6 [20.8 (10.9-45.6) vs. 12.9 (8.7-21.1) pg/ml, = 0.02], CRP [10.7 (4.2-19.2) vs. 5.9 (1.6-8.1) mg/dl, = 0.003], TNF-α [8.9 (6.0-14.8) vs. 4.4 (1.5-10.6) pg/ml, = 0.01], D-dimer [0.53 (0.25-0.72) vs. 0.22 (0.17-0.35) mg/l, = 0.002], and IL-10 [3.7 (1.8-6.9) vs. 2.3 (0.5-5.8) pg/ml, = 0.03]. A significant inverse correlation was found between 25OHD and all these markers, even adjusted for age and sex. Hypovitaminosis D was prevalent in patients with severe ARDS, compared with the other groups (75% vs. 68% vs. 55%, < 0.001), and 25OHD levels were lower in non-survivor patients.
Conclusions: The relationship between 25OHD levels and inflammatory markers suggests that vitamin D status needs to be taken into account in the management of these patients. If vitamin D is a marker of poor prognosis or a possible risk factor with beneficial effects from supplementation, this still needs to be elucidated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818986 | PMC |
| http://dx.doi.org/10.3389/fimmu.2021.745713 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
To Evaluate the Effect of Pediatric Massage Combined with Comprehensive Management on Growth Parameters and Biochemical Indicators in Children with Short Stature.
Int J Gen Med
August 2025
Department of Pediatrics, Fujian Medical University Union Hospital, Fujian, 350000, People's Republic of China.
Purpose: To investigated the effect of pediatric massage combined with comprehensive management on height improvement in children with short stature.
Patients And Methods: This retrospective analysis included medical records of 80 children diagnosed with short stature, who received treatment at Wuhu Hospital of Traditional Chinese Medicine between April 2022 and April 2023. According to the recorded treatment modalities, patients were divided into two groups: the control group received standard comprehensive management (including psychological health guidance, diet, sleep, exercise), while the massage group received additional pediatric syndrome-based massage therapy alongside comprehensive treatment.
Association between serum vitamin D metabolite levels and cognitive function in community-dwelling older adults: A cross-sectional study.
Clin Nutr ESPEN
September 2025
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, 2-1-132, Osaka-shi, Osaka 536-8525, JAPAN; Department of Endocrinology and Metabolism, Hospital, National Center for Geriatrics and Gerontology, 7-430 Moriokachō, Obu, Aichi, 474-0038, Japan. Electron
Background & Aims: Vitamin D deficiency has been associated with cognitive decline and Alzheimer's disease (AD); however, findings remain inconsistent. Assessing vitamin D status based solely on total 25-hydroxyvitamin D [25(OH)D] may be insufficient, and other metabolites, such as 24,25-dihydroxyvitamin D [24,25(OH)D] and 3-epimer-25-hydroxyvitamin D [3-epi-25(OH)D], may provide additional insights. This study aimed to examine the association between serum vitamin D metabolite concentrations and cognitive function in older adults.
View Article and Find Full Text PDFCorrelation between thyroid sensitivity indices and bone metabolism in newly diagnosed middle aged and elderly patients with type 2 diabetes mellitus with normal thyroid function.
BMC Endocr Disord
September 2025
Department of Endocrinology and Metabolism, Jiangxi Medical College, The Second Affiliated Hospital, Nanchang University, Nanchang City, 330006, Jiangxi Province, China.
Objective: To investigate the association between thyroid hormone sensitivity indices and bone metabolism markers in newly diagnosed middle-aged and elderly type 2 diabetes mellitus (T2DM) patients with normal thyroid function.
Method: We retrospectively analyzed 350 newly diagnosed T2DM patients (≥ 45 years), stratified by bone mineral density into Group A (normal bone density group) and Group B (low bone mass and osteoporosis group). General data and clinical biochemical parameters were collected: free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), serum calcium (Ca), serum phosphorus (P), fasting plasma glucose (FPG), glycosylated hemoglobinA1c (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum creatinine (SCr), serum uric acid (SUA), and estimated Glomerular Filtration Rate (eGFR).
Evaluation of vitamin D status, vitamin D receptor expression, and innate immune mediators in COVID-19.
Front Endocrinol (Lausanne)
September 2025
Molecular Testing Laboratory, Department of Medical Laboratory Sciences, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.
Background And Objectives: The Coronavirus disease 2019 (COVID-19) pandemic underscored the importance of identifying host factors that influence susceptibility to infection. Vitamin D signaling, mediated via its receptor (), along with innate immune mediators such as antimicrobial peptides (e.g.
View Article and Find Full Text PDFVitamin D insufficiency in pregnant women from Lebanon: prevalence and key predictors.
Reprod Health
September 2025
Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Background: Suboptimal 25-hydroxyvitamin D (25OHD) during pregnancy can have adverse maternal and neonatal outcomes.
Aim: This study aimed to estimate the prevalence of vitamin D deficiency in pregnant females in Lebanon and to identify its risk factors.
Methods: This is a cross-sectional study involving pregnant females identified during their first-early second trimester visit to obstetricians in two centers in Beirut.