Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background & Aims: Vitamin D deficiency has been associated with cognitive decline and Alzheimer's disease (AD); however, findings remain inconsistent. Assessing vitamin D status based solely on total 25-hydroxyvitamin D [25(OH)D] may be insufficient, and other metabolites, such as 24,25-dihydroxyvitamin D [24,25(OH)D] and 3-epimer-25-hydroxyvitamin D [3-epi-25(OH)D], may provide additional insights. This study aimed to examine the association between serum vitamin D metabolite concentrations and cognitive function in older adults.
Methods: A cross-sectional study was conducted involving 289 community-dwelling participants aged 65-85 years clinically diagnosed with AD, mild cognitive impairment (MCI), or were cognitively normal (CN). Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Serum concentrations of 25-hydroxyvitamin D [25(OH)D], 25(OH)D, 24,25(OH)D, 3-epi-25(OH)D, and 1,25-dihydroxyvitamin D [1,25(OH)D] were measured using LC-MS/MS. The Vitamin D metabolite ratio (VMR) was calculated as 24,25(OH)D/25(OH)D × 100 (%). Associations among metabolite concentrations, MMSE scores, and AD prevalence were analyzed.
Results: Participants had relatively high serum total 25(OH)D levels (median: 23.5 ng/mL), with males showing higher vitamin D metabolite concentrations. Total 25(OH)D correlated with 24,25(OH)D, 3-epi-25(OH)D, and VMR. In males, 3-epi-25(OH)D and 24,25(OH)D were associated with lower MMSE scores (p < 0.01) and higher AD risk (OR = 2.78, p = 0.03). In females, VMR was associated with higher MMSE scores (p = 0.01) and lower AD risk (OR = 0.64, p < 0.01), while 1,25(OH)D was linked to higher AD risk (OR = 1.04, p = 0.01) and quartile 2 with lower MCI risk (p < 0.05).
Conclusions: Sex-based differences in vitamin D-cognition associations may reflect disparities in vitamin D levels and hormonal effects, such as estrogen-enhancing and testosterone-suppressing metabolism. 1,25(OH)D, VMR, and 3-epi-25(OH)D may be more sensitive than total 25(OH)D.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clnesp.2025.08.032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients.
JCI Insight
September 2025
Division of Nephrology, Boston University Chobanian & Avedisian School of Medicine, Boston, United States of America.
Background: Active vitamin D metabolites, including 25-hydroxyvitamin D (25D) and 1,25-dihydroxyvitamin D (1,25D), have potent immunomodulatory effects that attenuate acute kidney injury (AKI) in animal models.
Methods: We conducted a phase 2, randomized, double-blind, multiple-dose, 3-arm clinical trial comparing oral calcifediol (25D), calcitriol (1,25D), and placebo among 150 critically ill adult patients at high-risk of moderate-to-severe AKI. The primary endpoint was a hierarchical composite of death, kidney replacement therapy (KRT), and kidney injury (baseline-adjusted mean change in serum creatinine), each assessed within 7 days following enrollment using a rank-based procedure.
Ciprofol Regulates the Activity of Mitochondrial Respiratory Chain Complex I During Cerebral Ischemia-Reperfusion by Targeting Flavin Mononucleotide: A Metabolomic Study.
J Integr Neurosci
August 2025
Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, 150001 Harbin, Heilongjiang, China.
Background And Purpose: Ciprofol, a novel intravenous anesthetic, has been shown to exert protective effects against ischemic stroke, a leading cause of death and disability; however, its molecular mechanisms remain unclear. This study aimed to explore the molecular mechanisms underlying the neuroprotective effects of ciprofol using metabolomics.
Methods: This study used a middle cerebral artery occlusion (MCAO) rat model to simulate cerebral ischemia-reperfusion injury (CIRI).
HIV-induced gut microbiota dysbiosis perpetuates mucosal barrier disruption and systemic inflammation despite antiretroviral therapy (ART), creating a tumor-permissive microenvironment. This review synthesizes evidence linking HIV-associated microbial alterations to oncogenesis through three convergent metabolic axes: (1) butyrate deficiency impairing epithelial energy metabolism and anti-tumor immunity; (2) tryptophan metabolism dysregulation compromising gut barrier integrity via depletion and -mediated phenylethylamine overproduction; and (3) vitamin B biosynthesis defects disrupting DNA repair and Th1/Th2 balance. Comparative profiling across HIV-associated malignancies-non-Hodgkin lymphoma, cervical cancer, hepatocellular carcinoma, and lung cancer-reveals conserved dysbiotic signatures: depletion of anti-inflammatory taxa (, ) and expansion of pro-inflammatory genera (, ).
View Article and Find Full Text PDFExploring vitamin D profile of epiphytic lichen forming fungi in forest ecosystems: Influence of habitat-dependent ecological variables.
Fungal Biol
October 2025
Marmara Forestry Research Institute Directorate, Fatih Forest Campus, Maslak-Sarıyer, Istanbul, Türkiye.
Vitamin D is critically important for sustainable human health, and the rising prevalence of deficiency-related diseases has increased interest in natural sources. This study explores the potential of epiphytic lichen-forming fungi, known for their unique metabolites, as a novel biosource of vitamin D for pharmaceutical and nutraceutical applications. Fourteen epiphytic lichen species were collected using a stratified sampling method from four mountainous forests in the Marmara Region of Türkiye.
View Article and Find Full Text PDFAssociation between serum vitamin D metabolite levels and cognitive function in community-dwelling older adults: A cross-sectional study.
Clin Nutr ESPEN
September 2025
Department of Nutrition, Graduate School of Human Life and Ecology, Osaka Metropolitan University, 2-1-132, Osaka-shi, Osaka 536-8525, JAPAN; Department of Endocrinology and Metabolism, Hospital, National Center for Geriatrics and Gerontology, 7-430 Moriokachō, Obu, Aichi, 474-0038, Japan. Electron
Background & Aims: Vitamin D deficiency has been associated with cognitive decline and Alzheimer's disease (AD); however, findings remain inconsistent. Assessing vitamin D status based solely on total 25-hydroxyvitamin D [25(OH)D] may be insufficient, and other metabolites, such as 24,25-dihydroxyvitamin D [24,25(OH)D] and 3-epimer-25-hydroxyvitamin D [3-epi-25(OH)D], may provide additional insights. This study aimed to examine the association between serum vitamin D metabolite concentrations and cognitive function in older adults.
View Article and Find Full Text PDF