98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1093/jn/nxab360 | DOI Listing |
J Comp Eff Res
September 2025
British Heart Foundation, University of Glasgow, Glasgow, UK.
Composite endpoints amalgamate multiple clinical outcomes into a single measure, offering efficiency gains in clinical trials through increased event rates and reduced sample sizes, thus accelerating clinical development and regulatory approval. However, employing composite endpoints introduces complexities into health technology assessments (HTAs), particularly in economic modeling, due to the varying clinical significance and cost implications of the components. In this paper, we explore best modeling practice for HTAs that are based on clinical trials that employ composite endpoints.
View Article and Find Full Text PDFGlob Chang Biol
September 2025
State Key Laboratory of Vegetation Structure, Function and Construction (VegLab), Institute of Ecology, and College of Urban and Environmental Sciences, Peking University, Beijing, China.
Increasingly frequent extreme droughts pose a serious threat to global vegetation. However, previous studies have not characterized the whole response process of vegetation to drought, and there are uncertainties in their methods and indicators. In this study, we developed a new indicator system and derived the response modes of global vegetation to extreme drought.
View Article and Find Full Text PDFJ Environ Qual
September 2025
Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.
Per- and polyfluoroalkyl substances (PFAS) in biosolid-amended soils can transfer and accumulate in crops, cattle, and people. Bioaccumulation factors (BAFs) are often applied to estimate the transfer of contaminants from soil to crops. However, they can vary widely and introduce uncertainty to exposure and risk estimates.
View Article and Find Full Text PDFISA Trans
July 2025
Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, 130033, China. Electronic address:
Coordinated operation of dual-arm manipulators is essential for enhancing the load capacity and adaptability of robotic systems. However, the precise control of the internal and external forces during the coordinated operation of dual-arm manipulators can pose considerable challenges owing to factors such as force interactions, kinematic constraints, positional inaccuracies, and external disturbances. This study focused on precise force-tracking control for a dual-arm manipulator system in the presence of external disturbances and uncertainties.
View Article and Find Full Text PDFRheumatol Int
September 2025
Department of Rheumatology, Reliant Medical Group, Worcester, MA, USA.
Background: VEXAS syndrome (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a recently identified autoinflammatory disorder caused by somatic UBA1 mutations. It presents with intractable systemic inflammation and hematologic abnormalities. Diagnostic delay and limited therapeutic consensus pose challenges in clinical practice.
View Article and Find Full Text PDF