Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here, we integrate high-confidence, systematically generated human, mouse, and fly data from studies on LDs in the framework of an online platform named the "Lipid Droplet Knowledge Portal" (https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9129885 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2022.01.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of fermentation, ripening and storage on endocannabinoids and endocannabinoid-like compounds in different cheeses.
Food Chem
September 2025
Food Quality and Safety (FoQuS) Research Group, Department of Food Engineering, Hacettepe University, 06800 Beytepe, Ankara, Turkey. Electronic address:
Endocannabinoids (ECs) and endocannabinoid-like (ECL) compounds are biologically active lipids derived from a range of fatty acids. This study aims to assess the levels and profile of ECs/ECL compounds across various cheeses, focusing particularly on how different processing steps such as fermentation, ripening, and storage affect their concentrations. Compared to commercial fresh and ripened cheeses, it was determined that ripening is of importance in shaping the profile of lipid signalling compounds.
View Article and Find Full Text PDFThe effect of sonicated cell-free supernatant from Lacticaseibacillus paracasei B1 and Lactiplantibacillusplantarum O24 on selected quality determinants of cooked pork sausages.
Meat Sci
September 2025
Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159C St., (Building No. 32), 02-776 Warsaw, Poland. Electronic address:
The aim of the study was to assess the effect of lyophilized cell-free supernatant (CFS) obtained from Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 cultures on the characteristics of cooked pork sausages stored by 21 days at 4 °C. The following parameters were assessed: antioxidant activity (ABTS, Reducing Power, Fe-chelating activity), texture parameters (hardness, springiness, gumminess, chewiness) and color changes (L*,a*,b*), as well as the fatty acid profile and TBARS content as an indicator of lipid oxidation. Microbiological status was also assessed.
View Article and Find Full Text PDFCurrent status of Liraglutide delivery systems for the management of type 2 diabetes mellitus.
Drug Deliv Transl Res
September 2025
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan, 333031, India.
Diabetes is a metabolic disorder of increasing global concern. Characterized by constantly elevated levels of glucose, severe β-cell dysfunction, and insulin resistance, it is the cause of a major burden on patients if not managed with therapeutic and lifestyle changes. The human body is slowly developing tolerance to many marketed antidiabetic drugs and the quest for the discovery of newer molecules continues.
View Article and Find Full Text PDFChitosan films incorporating bacterial cellulose-stabilized oregano oil emulsions: A functional approach for fresh walnut shelf-life extension.
Int J Biol Macromol
September 2025
School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, 201418, China. Electronic address:
Fresh walnuts are prone to moisture loss and spoilage after harvest, leading to reduced appearance and sensory quality. In this study, a multifunctional chitosan (CS)-based film was fabricated by incorporating a bacterial cellulose/oregano essential oil (BC/OEO) Pickering emulsion, with hydrogen bonding promoting cohesive matrix integration. The film's physicochemical properties, along with its antimicrobial and antioxidant activities, were systematically evaluated.
View Article and Find Full Text PDFExploring potential protein-protein interactions driving unusual fatty acid synthesis in pomegranate.
Plant Physiol Biochem
September 2025
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, T6G 2P5, Canada. Electronic address:
Many plant-derived unusual fatty acids (UFAs) possess valuable chemical properties and have potential applications in the food, feed, and oleochemical industries. Despite significant interest, the mechanisms by which plants synthesize and accumulate these structurally distinct fatty acids remain only partially understood. While enzyme substrate specificities involved in UFA-containing storage lipid assembly have been well characterized in many prior studies, the biochemical roles of protein-protein interactions (PPIs) in coordinating UFA biosynthesis have received less attention.
View Article and Find Full Text PDF